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核膜,一种全能的减数分裂“万金油”。

"The nuclear envelope, a meiotic jack-of-all-trades".

机构信息

Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Canada.

Department of Chromosome Biology, Max Perutz Laboratories, University of Vienna, Vienna Biocenter, Dr-Bohrgasse 9/5, Vienna, Austria.

出版信息

Curr Opin Cell Biol. 2020 Jun;64:34-42. doi: 10.1016/j.ceb.2019.12.010. Epub 2020 Feb 25.

Abstract

The nucleus is one of the membrane-bound organelles that are a distinguishing feature between eukaryotes and prokaryotes. During meiosis, the nuclear envelope takes on functions beyond separating the nucleoplasm from the cytoplasm. These include associations with meiotic chromosomes to mediate pairing, being a sensor for recombination progression, and supportive of enormous nuclear growth during oocyte formation. In this review, we highlight recent results that have contributed to our understanding of meiotic nuclear envelope function and dynamics.

摘要

核是真核生物和原核生物之间的区别特征之一,是一种有膜包被的细胞器。在减数分裂过程中,核膜除了将核质与细胞质分隔开之外,还具有其他功能。这些功能包括与减数分裂染色体的关联,以介导配对;作为重组进程传感器;支持卵母细胞形成过程中巨大的核生长。在这篇综述中,我们强调了最近有助于我们理解减数分裂核膜功能和动态的研究结果。

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