Shabani Saman, Kaushal Mayank, Budde Matthew D, Wang Marjorie C, Kurpad Shekar N
J Neurosurg Spine. 2020 Feb 28;33(1):65-72. doi: 10.3171/2019.12.SPINE191158. Print 2020 Jul 1.
Degenerative spondylotic myelopathy is the most common cause of spinal dysfunction, as well as nontraumatic spastic paraparesis and quadriparesis. Although conventional MRI is the gold standard for radiographic evaluation of the spinal cord, it has limited application for determining prognosis and recovery. In the last decade, diffusion tensor imaging (DTI), which is based on the property of preferential diffusion of water molecules, has gained popularity in evaluating patients with cervical spondylotic myelopathy (CSM). The use of DTI allows for evaluation of microstructural changes in the spinal cord not otherwise detected on routine conventional MRI. In this review, the authors describe the application of DTI in CSM evaluation and its role as an imaging biomarker to predict disease severity and prognosis.
退行性脊髓型颈椎病是脊髓功能障碍、非创伤性痉挛性截瘫和四肢瘫最常见的病因。尽管传统磁共振成像（MRI）是脊髓影像学评估的金标准，但在判断预后和恢复情况方面应用有限。在过去十年中，基于水分子优先扩散特性的扩散张量成像（DTI）在评估脊髓型颈椎病（CSM）患者中越来越受欢迎。DTI的应用能够评估脊髓的微观结构变化，而这些变化在常规传统MRI上无法检测到。在这篇综述中，作者描述了DTI在CSM评估中的应用及其作为一种成像生物标志物在预测疾病严重程度和预后方面的作用。
