Huang Lili, Wang Li, Peng Wei, Zhang Tiejun
Department of Anesthesiology, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, People's Republic of China.
Ther Clin Risk Manag. 2020 Feb 20;16:103-108. doi: 10.2147/TCRM.S242952. eCollection 2020.
This study aims to investigate the effects of trans-cricothyroid membrane injection of local anesthesia on cough response and postoperative sore throat to the nasotracheal tube.
Patients who require general anesthesia with nasotracheal tube for oral and maxillofacial surgery were randomised divided into groups L and C. The patients in group L received trans-cricothyroid membrane injection of 2% lidocaine (3 mL) before anesthesia. Meanwhile, the same volume of 0.9% saline was administered to group C. The incidences of cough response, mean arterial pressure (MAP) and heart rate (HR) were recorded during emergency from general anesthesia. Postoperative sore throat (POST) was assessed at 1, 6, 12 and 24 h after surgery.
The data of 60 patients in group L and 61 in group C were included in this study. The incidence of cough was lower in group L than in group C, ie, 41.7% vs 67.2% upon extubation (=0.006) and 20.0% vs 41.0% at five minutes after extubation (=0.018). MAP and HR in group L were significantly lower than in group C during emergency from general anesthesia (<0.05). POST incidence was significantly reduced in group L at 1 and 6 h after surgery, ie, 35.0% vs 55.7% at 1 h after surgery (=0.029) and 20.0% vs 37.7% at 6 h after surgery (=0.044).
Trans-cricothyroid membrane injection of local anesthesia is a simple and effective method to attenuate the incidence of cough response during emergency from general anesthesia. This technique can reduce the incidence of POST after surgery.
本研究旨在探讨经环甲膜注射局部麻醉药对咳嗽反应及术后经鼻气管导管所致咽痛的影响。
需行口腔颌面外科手术并经鼻气管插管全身麻醉的患者随机分为L组和C组。L组患者在麻醉前经环甲膜注射2%利多卡因(3 mL)。同时,C组给予相同体积的0.9%生理盐水。记录全身麻醉诱导期咳嗽反应、平均动脉压(MAP)和心率(HR)的发生率。术后1、6、12和24小时评估咽痛(POST)情况。
本研究纳入了L组60例患者和C组61例患者的数据。L组咳嗽发生率低于C组,即拔管时分别为41.7%和67.2%(P = 0.006),拔管后5分钟时分别为20.0%和41.0%(P = 0.018)。全身麻醉诱导期L组的MAP和HR显著低于C组(P < 0.05)。L组术后1和6小时的POST发生率显著降低,即术后1小时分别为35.0%和55.7%(P = 0.029),术后6小时分别为20.0%和37.7%(P = 0.044)。
经环甲膜注射局部麻醉药是一种简单有效的方法,可降低全身麻醉诱导期咳嗽反应的发生率。该技术可降低术后POST的发生率。