Allen A D
Biomedical Sciences Division, Algorithms, Incorporated, Northridge, California 91325.
Med Hypotheses. 1988 Nov;27(3):217-20. doi: 10.1016/0306-9877(88)90146-6.
Patients with chronic fatigue syndromes (primary fibrositis syndrome, major affective disorder, etc.) have elevated IgG serum antibodies to multiple common viruses. Only IgG rubella antibodies are positively correlated with the intensity of symptoms and have a height that is clearly significant compared to healthy controls. The lymphotropic properties of the rubella virus could account for the multiple elevated antibodies. Adult women are over-represented in the population of patients with chronic fatigue, and are especially susceptible to developing such symptoms following exposure to attenuated rubella virus. A new more potent strain of live rubella vaccine (strain RA27/3) was introduced in 1979. Within three years reports of patients with chronic fatigue began surfacing in the literature. Considering all this, the possible role of rubella immunization in the etiology of chronic fatigue syndromes deserves further study.
患有慢性疲劳综合征（原发性纤维肌痛综合征、重度情感障碍等）的患者血清中针对多种常见病毒的IgG抗体升高。只有IgG风疹抗体与症状强度呈正相关，且与健康对照相比其水平明显升高。风疹病毒的嗜淋巴细胞特性可能解释了多种抗体升高的原因。成年女性在慢性疲劳患者群体中占比过高，并且在接触减毒风疹病毒后特别容易出现此类症状。1979年引入了一种新的、效力更强的风疹活疫苗株（RA27/3株）。在三年内，关于慢性疲劳患者的报告开始出现在文献中。考虑到所有这些，风疹免疫在慢性疲劳综合征病因学中的可能作用值得进一步研究。
