异三聚体纳米颗粒的自下而上自组装及其第二代Janus颗粒

Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations.

作者信息

Fu Jianye, Gu Zhengying, Liu Yang, Zhang Jun, Song Hao, Yang Yannan, Yang Yang, Noonan Owen, Tang Jie, Yu Chengzhong

机构信息

Australian Institute for Bioengineering and Nanotechnology , The University of Queensland , St Lucia , Brisbane , QLD 4072 , Australia . Email:

School of Chemistry and Molecular Engineering , East China Normal University , Shanghai 200241 , P. R. China . Email:

出版信息

Chem Sci. 2019 Sep 19;10(44):10388-10394. doi: 10.1039/c9sc02961c. eCollection 2019 Nov 28.

A bottom-up self-assembly approach is developed for the synthesis of type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an epithelial monolayer model mimicking the human intestinal epithelium.