Gifford Carol H, Morris Anita P, Kenney Kurt J, Estep J Scot
Riverside Veterinary Care and Dental Services, Rutland, VT, USA.
Animal Sound, Woodstock, VT, USA.
JFMS Open Rep. 2020 Feb 3;6(1):2055116919894782. doi: 10.1177/2055116919894782. eCollection 2020 Jan-Jun.
A 14-year-old male neutered Maine Coon cat presented with a 6-month history of polyphagia and one recent episode of tremors and weakness. Blood work revealed profound hypoglycemia and results of a paired insulin glucose test were consistent with an insulinoma. Abdominal ultrasound revealed a solitary pancreatic mass, and results of a fine-needle aspirate (FNA) gave further support for the location of the neuroendocrine tumor. After unsuccessful medical management of the hypoglycemia, the mass was surgically removed. Immunohistochemistry confirmed that it was an insulinoma. At the time of writing, the patient had been in clinical remission for 9 months.
Feline insulinomas are rare and there is very little information on their behavior, clinical course and histologic characteristics. This is the first reported case of an insulinoma in a Maine Coon cat and the first to describe results of an ultrasound-guided FNA of the mass. In addition, the progression of disease, histopathology and immunohistochemistry results add to the currently minimal database for feline insulinomas.
一只14岁已绝育的缅因库恩猫出现了6个月的多食病史，近期有一次震颤和虚弱发作。血液检查显示严重低血糖，胰岛素葡萄糖配对试验结果与胰岛素瘤相符。腹部超声显示胰腺有一个孤立性肿块，细针穿刺抽吸（FNA）结果进一步支持了神经内分泌肿瘤的位置。在低血糖的药物治疗失败后，该肿块被手术切除。免疫组织化学证实其为胰岛素瘤。在撰写本文时，该患者已临床缓解9个月。
猫胰岛素瘤很罕见，关于其行为、临床病程和组织学特征的信息非常少。这是第一例报道的缅因库恩猫胰岛素瘤病例，也是第一例描述肿块超声引导下细针穿刺抽吸结果的病例。此外，疾病进展、组织病理学和免疫组织化学结果增加了目前关于猫胰岛素瘤的极少数据库内容。
