Becker Tamara, Pieper Florian, Liebetanz David, Bleyer Martina, Schrod Annette, Maetz-Rensing Kerstin, Treue Stefan
German Primate Center, 37077 Göttingen, Germany.
Georg August University, University Hospital, 37075 Göttingen, Germany.
Primate Biol. 2017 Mar 7;4(1):27-32. doi: 10.5194/pb-4-27-2017. eCollection 2017.
Guillain-Barré syndrome (GBS) is a rare, mainly acute inflammatory polyneuropathy in humans. It is frequently post-infectious with auto antibodies being formed against myelin sheaths, resulting in a progressive and more-or-less severe paralysis of the motor neuron and cranial nerves. Mortality is low and 60 % of the patients recover completely from the disease after intensive treatment. In animals, there are a few diseases that closely resemble GBS, but cases of GBS in monkeys seem to be scarce. In this case report, the clinical course of a progressive tetraplegia in a male rhesus macaque is described. Clinical, cerebrospinal fluid (CSF), electroneurography (ENG) and electromyography (EMG), and pathological findings revealed symptoms very similar to human GBS.
吉兰-巴雷综合征（GBS）是一种罕见的、主要发生在人类的急性炎症性多发性神经病。它常继发于感染后，机体产生针对髓鞘的自身抗体，导致运动神经元和颅神经进行性、轻重不一的麻痹。死亡率较低，60%的患者经强化治疗后可完全康复。在动物中，有几种疾病与GBS非常相似，但猴子患GBS的病例似乎很少。在本病例报告中，描述了一只雄性恒河猴进行性四肢瘫痪的临床过程。临床、脑脊液（CSF）、神经电图（ENG）和肌电图（EMG）以及病理检查结果显示，其症状与人类GBS非常相似。
