Lampe Karen, Rudnick Jens-Christian, Leendertz Fabian, Bleyer Martina, Mätz-Rensing Kerstin
Pathology Unit, German Primate Center, Leibniz-Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany.
Tierklinik-Tierheim GmbH Rostock, Thierfelderstraße 19, 18059 Rostock, Germany.
Primate Biol. 2017 Mar 8;4(1):39-46. doi: 10.5194/pb-4-39-2017. eCollection 2017.
A 9-year-old female captive patas monkey () presented with poor general condition, inability to stand, petechiae, anaemia, thrombocytopenia, and leukocytosis. Due to poor response to treatment, the animal was euthanized 16 days later. Postmortem examination revealed hemorrhages in several organs and bilateral cerebral infarctions. Histologically, prominent accumulations of large neoplastic lymphocytes in cerebral and meningeal blood vessels were demonstrated within the lesions and in other organs (e.g., bone marrow, ovary, intestine). Immunohistochemically, neoplastic cells expressed CD3 and Ki-67. PCR revealed a lymphocryptovirus (LCV) infection, while Epstein-Barr nuclear antigen 2 (EBNA2) could not be demonstrated within neoplastic cells by means of immunohistochemistry. Based on the pathological findings, an intravascular lymphoma (IVL) of T-cell origin was diagnosed. To the authors' knowledge, this is the first report on this rare entity in a nonhuman primate.
一只9岁的圈养雌性赤猴出现全身状况不佳、无法站立、瘀点、贫血、血小板减少和白细胞增多。由于对治疗反应不佳，该动物在16天后实施安乐死。尸检发现多个器官有出血和双侧脑梗死。组织学检查显示，病变部位及其他器官（如骨髓、卵巢、肠道）的脑和脑膜血管中有大量肿瘤性淋巴细胞显著聚集。免疫组化显示，肿瘤细胞表达CD3和Ki-67。聚合酶链反应检测发现淋巴隐病毒（LCV）感染，而通过免疫组化在肿瘤细胞内未检测到EB病毒核抗原2（EBNA2）。根据病理结果，诊断为T细胞源性血管内淋巴瘤（IVL）。据作者所知，这是关于非人类灵长类动物中这种罕见疾病的首例报告。
