Plesker Roland, Bleyer Martina, Mätz-Rensing Kerstin
Paul-Ehrlich-Institut, Langen, 63225, Germany.
Pathology Unit, German Primate Center, Göttingen, 37077, Germany.
Primate Biol. 2018 Apr 5;5(1):7-13. doi: 10.5194/pb-5-7-2018. eCollection 2018.
We present a case of spontaneous meningioma in a female pig-tailed macaque () more than 24 years old. Clinically, the monkey displayed slow, weak, and insecure movements and poor vision. A tumorous mass was present at the floor of the cranial vault extending from the optic chiasm towards the foramen magnum. It compressed adjacent parts of the brain, infiltrated the sphenoidal and occipital bone, and showed transcranial expansion into the pharyngeal area. Histologically, the tumor was consistent with a meningioma displaying mostly meningothelial and some microcystic components. Since only six cases of meningiomas in nonhuman primates have been reported so far and only two of these meningiomas have been described in detail, the findings of each case should be reported to expand the knowledge base of this type of tumor. In addition, this is the first description of a meningioma in pig-tailed macaques.
我们报告一例24岁以上雌性豚尾猕猴自发性脑膜瘤的病例。临床上，这只猴子表现出动作缓慢、虚弱且不稳以及视力不佳。颅顶底部有一个肿瘤块，从视交叉延伸至枕骨大孔。它压迫了大脑的相邻部位，浸润了蝶骨和枕骨，并经颅扩展至咽部区域。组织学上，该肿瘤符合脑膜瘤，主要表现为脑膜内皮和一些微囊成分。由于迄今为止仅报道了6例非人类灵长类动物的脑膜瘤病例，且其中仅有2例得到详细描述，因此应报告每例病例的研究结果以扩充此类肿瘤的知识库。此外，这是豚尾猕猴脑膜瘤的首次描述。
