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1个月以上儿童细菌性脑膜炎致病原的抗生素敏感性

Antibiotic Susceptibility of Bacterial Agents Causing Meningitis in Children Older than 1 Month.

作者信息

Mohsenipour Reihaneh, Gharib Behdad, Eshaghi Hamid, Rahmani Parisa

机构信息

Department of Pediatric Endocrinology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Department of Pediatrics, School of Medicine, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Drug Res (Stuttg). 2020 Apr;70(4):174-177. doi: 10.1055/a-1112-7006. Epub 2020 Feb 28.

Abstract

The frequency and antibiotic susceptibility of bacterial meningitis in children older than one month at Children's Medical Center during 2012-2017 were evaluated in this study. The CSF samples were cultured, and antibiotic sensitivity tests were performed. The samples were cultured on chocolate agar, blood agar (for gram positive) and Mkanky (for gram negative). The antimicrobial susceptibility of the isolates was determined using the disc diffusion method. In total, 72 samples were positive for bacterial infection where Staphylococcus epidermidis (20.8%) was seen most and Enterobacter (1.4%) and Pseudomonas aeruginosa (1.4%) was seen least. Most of these patients were under 1 year of the age and overall frequency of positive cultures of CSF in men (58.3%) was greater than women (41.7%). Bacterial meningitis has relatively diverse etiological factors that include; time of infection, geographical location and age. Most commonly seen bacteria were Staphylococcus aureus with S.epidermidis whereas, Escherichia coli and Pseudomonas aeruginosa was seen least. This result can be substantial in hospitalized patients, because these bacteria are also the result of nosocomial infections.

摘要

本研究评估了2012年至2017年期间儿童医学中心1个月以上儿童细菌性脑膜炎的发病率及抗生素敏感性。对脑脊液样本进行培养,并进行抗生素敏感性测试。样本在巧克力琼脂、血琼脂(用于革兰氏阳性菌)和麦康凯琼脂(用于革兰氏阴性菌)上培养。采用纸片扩散法测定分离株的抗菌药敏性。共有72份样本细菌感染呈阳性,其中表皮葡萄球菌(20.8%)最为常见,肠杆菌(1.4%)和铜绿假单胞菌(1.4%)最少见。这些患者大多年龄在1岁以下,脑脊液培养阳性的总体发生率男性(58.3%)高于女性(41.7%)。细菌性脑膜炎的病因相对多样,包括感染时间、地理位置和年龄。最常见的细菌是金黄色葡萄球菌和表皮葡萄球菌,而大肠杆菌和铜绿假单胞菌最少见。这一结果对住院患者意义重大,因为这些细菌也是医院感染的病原体。

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