Department of Respiratory Medicine, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia.
School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, NSW, Australia.
J Cyst Fibros. 2020 Sep;19(5):700-703. doi: 10.1016/j.jcf.2020.02.009. Epub 2020 Feb 25.
It is not yet known whether continuous glucose monitoring (CGM) abnormalities persist in young children with CF. We evaluated longitudinal CGM results for children with CF < 10 years of age. We performed 3-day CGM at baseline, 12 months, and 24 months on 11 CF children (1 female) initially aged mean (SD) 3.8 (2.5) years. CGM analysis included (i) mean sensor glucose (SG), (ii) standard deviation (SD) for SG, (iii) peak SG and (iv)% time spent above a threshold of 7.8 mmol/L. Only three (3/11, 27%) had normal CGM at all time-points. Nearly three quarters of the participants (8/11, 73%) spent more than 4.5 percent time > 7.8 mmol/L at one time-point, five of whom had an elevated percent time on a subsequent test. Young children with CF have glucose abnormalities detected by CGM that fluctuate over time.
目前尚不清楚囊性纤维化（CF）患儿的持续血糖监测（CGM）异常是否持续存在。我们评估了年龄<10 岁的 CF 儿童的纵向 CGM 结果。我们对 11 名 CF 儿童（1 名女性）进行了为期 3 天的 CGM 检测，基线时、12 个月和 24 个月时他们的平均（SD）年龄分别为 3.8（2.5）岁。CGM 分析包括（i）平均传感器血糖（SG），（ii）SG 的标准差（SD），（iii）峰值 SG 和（iv）%时间花费在 7.8mmol/L 以上的阈值。只有三人（3/11，27%）在所有时间点均有正常 CGM。近四分之三的参与者（8/11，73%）在一个时间点上有超过 4.5%的时间>7.8mmol/L，其中 5 人在随后的测试中有升高的%时间。通过 CGM 检测到的 CF 幼儿的血糖异常随时间波动。
