Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea
In Vivo. 2020 Mar-Apr;34(2):815-824. doi: 10.21873/invivo.11843.
BACKGROUND/AIM: Bone tissue engineering is an emerging field of regenerative medicine that holds promise for the restoration of bones affected by trauma, neoplastic diseases, and congenital deformity. During the past decade, bone tissue engineering has evolved from the use of biomaterials that can only replace small areas of damaged bone, to the use of scaffolds in which grafts can be seeded before implantation. This case report proposes an alternative option for a veterinary patient suffering from ectrodactyly, which is one of several congenital deformities in dogs. A 2-month-old male toy poodle dog with ectrodactyly was treated using several stages of surgery involving pancarpal arthrodesis, limb lengthening, and bone tissue engineering techniques.
Over a period of 2 years, the operated limb gained almost the same function as the contralateral limb. Bone tissue engineering techniques can be used for the treatment of congenital deformities in dogs.
背景/目的：骨组织工程学是再生医学的一个新兴领域，有望恢复因创伤、肿瘤疾病和先天畸形而受损的骨骼。在过去的十年中，骨组织工程学已经从使用只能替代小块受损骨骼的生物材料发展到使用支架，在植入前可以在支架中接种移植物。本病例报告为患有并指畸形（狗的几种先天畸形之一）的兽医患者提供了一种替代方案。一只 2 个月大的雄性玩具贵宾犬患有并指畸形，通过多阶段手术进行治疗，包括全跗关节融合术、肢体延长术和骨组织工程技术。
在 2 年的时间里，手术肢体获得了与对侧肢体几乎相同的功能。骨组织工程技术可用于治疗狗的先天畸形。
