产后生长与早产儿视网膜病变（G-ROP）研究中早产儿视网膜病变改良筛查标准的经济影响评估。
Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study.
作者信息
Zupancic John A F, Ying Gui-Shuang, de Alba Campomanes Alejandra, Tomlinson Lauren A, Binenbaum Gil
机构信息
Division of Newborn Medicine, Harvard Medical School, Boston, MA, USA.
Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
出版信息
J Perinatol. 2020 Jul;40(7):1100-1108. doi: 10.1038/s41372-020-0605-5. Epub 2020 Feb 28.
IMPORTANCE
The Postnatal Growth and Retinopathy of Prematurity (G-ROP) Study showed that the addition of postnatal weight gain to birth weight and gestational age detects similar numbers of infants with ROP, but requires examination of fewer infants.
OBJECTIVE
To determine the incremental cost-effectiveness of screening with G-ROP compared with conventional screening.
DESIGN, SETTING AND PARTICIPANTS: We built a microsimulation model of a 1-year US birth cohort <32 weeks gestation, using data from the G-ROP study. We obtained resource utilization estimates from the G-ROP dataset and from secondary sources, and test characteristics from the G-ROP cohort.
RESULTS
Among 78,281 infants nationally, screening with G-ROP detected ~25 additional infants with Type 1 ROP. This was accomplished with 36,233 fewer examinations, in 14,073 fewer infants, with annual cost savings of approximately US$2,931,980 through hospital discharge.
CONCLUSIONS
Screening with G-ROP reduced costs while increasing the detection of ROP compared with current screening guidelines.
重要性
早产产后生长与视网膜病变（G-ROP）研究表明，将出生后体重增加纳入出生体重和胎龄可检测出数量相近的患有视网膜病变（ROP）的婴儿，但所需检查的婴儿数量更少。
目的
确定与传统筛查相比，采用G-ROP筛查的增量成本效益。
设计、背景与参与者：我们利用G-ROP研究的数据构建了一个美国1年出生队列（孕周<32周）的微观模拟模型。我们从G-ROP数据集和二手资料中获取资源利用估计值，并从G-ROP队列中获取检测特征。
结果
在全国78,281名婴儿中，采用G-ROP筛查可多检测出约25名患有1型ROP的婴儿。这通过减少36,233次检查、减少14,073名婴儿的检查实现，到出院时每年节省成本约2,931,980美元。
结论
与当前筛查指南相比，采用G-ROP筛查可降低成本，同时增加ROP的检测率。
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