用于细胞群体体内成像的蛋白酶激活传感器。

Protease-Activated Sensors for In Vivo Imaging of Cell Populations.

机构信息

Department of Chemistry, Kansas State University, Manhattan, KS, USA.

Department of Chemistry and Johnson Cancer Center, Kansas State University, Manhattan, KS, USA.

出版信息

Methods Mol Biol. 2020;2126:117-126. doi: 10.1007/978-1-0716-0364-2_11.

DOI:10.1007/978-1-0716-0364-2_11

PMID:32112384

Abstract

Biosensors are important devices that can be used to obtain information from within a living organism. They can be implanted within living tissues in order to continuously monitor for changes. This allows for personalized, noninvasive medicine, since a baseline can be more accurately established and any deviations, even slight, can be detected. These devices have applications in the treatment of diseases such as diabetes and cancer, as well as the study of pathways of interest and tailored drug dosing. Proteases within the tumor microenvironment can be studied in vivo in order to indicate the effectiveness of treatments received. This unprecedented real-time information is extremely valuable as it can be used to alter the course of treatment accordingly.

摘要

生物传感器是一种重要的设备，可以用于获取活体组织内的信息。它们可以被植入活体组织内，以便持续监测变化。这使得个性化、非侵入性的医学成为可能，因为可以更准确地建立基线，并且可以检测到任何偏差，即使是微小的偏差。这些设备在糖尿病和癌症等疾病的治疗以及感兴趣途径和定制药物剂量的研究中有应用。可以在体内研究肿瘤微环境中的蛋白酶，以指示所接受治疗的效果。这种前所未有的实时信息非常有价值，因为它可以用于相应地改变治疗方案。