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Antithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin.

作者信息

Rezaie Alireza R, Giri Hemant

机构信息

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

出版信息

J Thromb Haemost. 2020 Mar;18(3):528-533. doi: 10.1111/jth.14724.

DOI:10.1111/jth.14724
PMID:32112532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7080319/
Abstract
摘要

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2
The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation.抗凝血酶的P1残基对靶蛋白酶特异性很重要，但对丝氨酸蛋白酶抑制剂的肝素激活不重要。具有改变的蛋白酶特异性但肝素激活正常的P1抗凝血酶变体的表征。
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本文引用的文献

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A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection.一种人抗凝血酶同工型可在细菌感染期间抑制炎症反应并保护器官免受损伤。
Nat Microbiol. 2019 Dec;4(12):2442-2455. doi: 10.1038/s41564-019-0559-6. Epub 2019 Sep 23.
2
Comparison of biological activities of human antithrombins with high-mannose or complex-type nonfucosylated N-linked oligosaccharides.具有高甘露糖型或复杂型非岩藻糖基化N-连接寡糖的人抗凝血酶生物活性比较。
Glycobiology. 2016 May;26(5):482-92. doi: 10.1093/glycob/cww001. Epub 2016 Jan 7.
3
CD13 restricts TLR4 endocytic signal transduction in inflammation.
抗凝血酶与内皮硫酸乙酰肝素之间的相互作用减轻创伤和失血性休克后的肺血栓炎症。
Shock. 2025 Apr 1;63(4):638-647. doi: 10.1097/SHK.0000000000002543. Epub 2025 Jan 23.
4
Disseminated intravascular coagulation: cause, molecular mechanism, diagnosis, and therapy.弥散性血管内凝血：病因、分子机制、诊断与治疗
MedComm (2020). 2025 Jan 14;6(2):e70058. doi: 10.1002/mco2.70058. eCollection 2025 Feb.
5
Influence of albumin concentration on surface characteristics and cellular responses in the pre-incubation of multi-walled carbon nanotubes.白蛋白浓度对多壁碳纳米管预孵育中表面特性和细胞反应的影响。
Nanoscale Adv. 2024 Oct 10;6(22):5585-97. doi: 10.1039/d4na00743c.
6
Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia.内毒素血症时重组血栓调节蛋白和重组抗凝血酶可减轻呼吸机所致肺损伤时肺血管内皮糖萼降解和中性粒细胞胞外诱捕网形成。
Respir Res. 2024 Sep 3;25(1):330. doi: 10.1186/s12931-024-02958-0.
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Front Immunol. 2023 Apr 14;14:1158457. doi: 10.3389/fimmu.2023.1158457. eCollection 2023.
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Front Immunol. 2022 Dec 9;13:1026163. doi: 10.3389/fimmu.2022.1026163. eCollection 2022.
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PLoS One. 2022 Nov 14;17(11):e0277641. doi: 10.1371/journal.pone.0277641. eCollection 2022.
CD13在炎症中限制Toll样受体4（TLR4）的内吞信号转导。
J Immunol. 2015 May 1;194(9):4466-76. doi: 10.4049/jimmunol.1403133. Epub 2015 Mar 23.
4
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Thromb Haemost. 2015 Feb;113(2):338-49. doi: 10.1160/TH14-04-0360. Epub 2014 Sep 18.
5
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PLoS One. 2014 Jul 21;9(7):e102577. doi: 10.1371/journal.pone.0102577. eCollection 2014.
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J Thromb Haemost. 2014 Sep;12(9):1470-9. doi: 10.1111/jth.12643. Epub 2014 Jul 16.
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Immunology. 2012 Mar;135(3):226-35. doi: 10.1111/j.1365-2567.2011.03528.x.