Antithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin.
作者信息
Rezaie Alireza R, Giri Hemant
机构信息
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
出版信息
J Thromb Haemost. 2020 Mar;18(3):528-533. doi: 10.1111/jth.14724.
Abstract
摘要
相似文献
1
Antithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin.
J Thromb Haemost. 2020 Mar;18(3):528-533. doi: 10.1111/jth.14724.
2
The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation.
Biochemistry. 2001 Jun 5;40(22):6670-9. doi: 10.1021/bi002933d.
3
Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin.
FEBS Lett. 2009 Oct 6;583(19):3165-70. doi: 10.1016/j.febslet.2009.07.062. Epub 2009 Sep 1.
4
Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin.
Lab Invest. 2008 Mar;88(3):306-17. doi: 10.1038/labinvest.3700717. Epub 2008 Jan 14.
5
Anticoagulant and signaling functions of antithrombin.
J Thromb Haemost. 2020 Dec;18(12):3142-3153. doi: 10.1111/jth.15052. Epub 2020 Sep 9.
6
Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants.
Trends Cardiovasc Med. 2002 Jul;12(5):198-205. doi: 10.1016/s1050-1738(02)00160-3.
7
Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases.
Biochem J. 1998 Nov 1;335 ( Pt 3)(Pt 3):701-9. doi: 10.1042/bj3350701.
8
Is the antithrombotic effect of sulfated galactans independent of serpin?
J Thromb Haemost. 2014 Jan;12(1):43-53. doi: 10.1111/jth.12448.
9
General features of the heparin-binding serpins antithrombin, heparin cofactor II and protein C inhibitor.
Blood Coagul Fibrinolysis. 1993 Jun;4(3):479-90. doi: 10.1097/00001721-199306000-00013.
10
Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis.
Front Cardiovasc Med. 2022 May 3;9:878199. doi: 10.3389/fcvm.2022.878199. eCollection 2022.
引用本文的文献
1
Changes in the pulmonary surfactant in patients with mild to moderate COVID-19.
PLoS One. 2025 Aug 7;20(8):e0325153. doi: 10.1371/journal.pone.0325153. eCollection 2025.
2
Antithrombin regulates neutrophil activities through the stimulation of C-type lectin family 1A.
Blood Vessel Thromb Hemost. 2024 Oct 8;2(1):100032. doi: 10.1016/j.bvth.2024.100032. eCollection 2025 Feb.
3
THE INTERACTION BETWEEN ANTITHROMBIN AND ENDOTHELIAL HEPARAN SULFATE MITIGATES PULMONARY THROMBOINFLAMMATION AFTER TRAUMA AND HEMORRHAGIC SHOCK.
Shock. 2025 Apr 1;63(4):638-647. doi: 10.1097/SHK.0000000000002543. Epub 2025 Jan 23.
4
Disseminated intravascular coagulation: cause, molecular mechanism, diagnosis, and therapy.
MedComm (2020). 2025 Jan 14;6(2):e70058. doi: 10.1002/mco2.70058. eCollection 2025 Feb.
5
Influence of albumin concentration on surface characteristics and cellular responses in the pre-incubation of multi-walled carbon nanotubes.
Nanoscale Adv. 2024 Oct 10;6(22):5585-97. doi: 10.1039/d4na00743c.
6
Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia.
Respir Res. 2024 Sep 3;25(1):330. doi: 10.1186/s12931-024-02958-0.
7
Anticoagulation in renal replacement therapies: Why heparin should be abandoned in critical ill patients?
Int Urol Nephrol. 2024 Apr;56(4):1383-1393. doi: 10.1007/s11255-023-03805-9. Epub 2023 Sep 27.
8
A 3--sulfated heparan sulfate dodecasaccharide (12-mer) suppresses thromboinflammation and attenuates early organ injury following trauma and hemorrhagic shock.
Front Immunol. 2023 Apr 14;14:1158457. doi: 10.3389/fimmu.2023.1158457. eCollection 2023.
9
Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes.
Front Immunol. 2022 Dec 9;13:1026163. doi: 10.3389/fimmu.2022.1026163. eCollection 2022.
10
Risk factors for mechanical ventilation and ECMO in COVID-19 patients admitted to the ICU: A multicenter retrospective observational study.
PLoS One. 2022 Nov 14;17(11):e0277641. doi: 10.1371/journal.pone.0277641. eCollection 2022.
本文引用的文献
1
A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection.
Nat Microbiol. 2019 Dec;4(12):2442-2455. doi: 10.1038/s41564-019-0559-6. Epub 2019 Sep 23.
2
Comparison of biological activities of human antithrombins with high-mannose or complex-type nonfucosylated N-linked oligosaccharides.
Glycobiology. 2016 May;26(5):482-92. doi: 10.1093/glycob/cww001. Epub 2016 Jan 7.
3
CD13 restricts TLR4 endocytic signal transduction in inflammation.
J Immunol. 2015 May 1;194(9):4466-76. doi: 10.4049/jimmunol.1403133. Epub 2015 Mar 23.
4
Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury.
Thromb Haemost. 2015 Feb;113(2):338-49. doi: 10.1160/TH14-04-0360. Epub 2014 Sep 18.
5
Antimicrobial effects of helix D-derived peptides of human antithrombin III.
J Biol Chem. 2014 Oct 24;289(43):29790-800. doi: 10.1074/jbc.M114.570465. Epub 2014 Sep 8.
6
A peptide of heparin cofactor II inhibits endotoxin-mediated shock and invasive Pseudomonas aeruginosa infection.
PLoS One. 2014 Jul 21;9(7):e102577. doi: 10.1371/journal.pone.0102577. eCollection 2014.
7
Antithrombin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study.
J Thromb Haemost. 2014 Sep;12(9):1470-9. doi: 10.1111/jth.12643. Epub 2014 Jul 16.
8
Syndecan-4 signaling at a glance.
J Cell Sci. 2013 Sep 1;126(Pt 17):3799-804. doi: 10.1242/jcs.124636. Epub 2013 Aug 22.
9
Proteolytic activation transforms heparin cofactor II into a host defense molecule.
J Immunol. 2013 Jun 15;190(12):6303-10. doi: 10.4049/jimmunol.1203030. Epub 2013 May 8.
10
CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.
Immunology. 2012 Mar;135(3):226-35. doi: 10.1111/j.1365-2567.2011.03528.x.
Zotero 插件