Lister R G, Sunderland T, Weingartner H J
Laboratory of Clinical Studies, NIAAA, Bethesda, MD 20892.
Neurobiol Aging. 1988 Sep-Dec;9(5-6):505-6. doi: 10.1016/s0197-4580(88)80105-2.
Useful models of age-related human and animal memory changes should simulate specific features of cognitive impairment associated with aging. It is necessary but not sufficient to demonstrate that manipulations such as those produced by lesions and drugs cause impairments in some cognitive function such as memory. A useful model should be able to reproduce a pattern of cognitive changes in which islands of spared versus impaired functioning resemble those associated with aging and differ from those produced by other conditions. This requires the use of research strategies utilizing multivariate treatment and dependent measure designs. The papers in this section illustrate the value of such a research approach.
有用的人类和动物与年龄相关的记忆变化模型应模拟与衰老相关的认知障碍的特定特征。证明诸如损伤和药物所产生的操作会导致某些认知功能（如记忆）受损是必要的，但并不充分。一个有用的模型应该能够重现一种认知变化模式，其中功能保留与受损的区域类似于与衰老相关的区域，并且与其他情况所产生的区域不同。这需要使用采用多变量处理和相关测量设计的研究策略。本节中的论文说明了这种研究方法的价值。
