血清 S100B 水平与 2 型糖尿病患者认知功能障碍有关。
Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes.
机构信息
Department of Pediatrics, Tianjin Children's Hospital, Beichen, Tianjin, PR China.
Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, PR China.
出版信息
Aging (Albany NY). 2020 Feb 29;12(5):4193-4203. doi: 10.18632/aging.102873.
OBJECTIVE
Previous studies have provided robust evidence that cognitive impairment exists in patients with type 2 diabetes. The predictive role of S100B in a variety of neurodegenerative diseases such as Alzheimer's disease, has been shown to be closely related to cognitive function. The purpose of this study was to investigate the correlation between serum S100B levels and cognitive function in type 2 diabetes patients.
RESULTS
The type 2 diabetes group scored lower than the healthy control group in all domains of cognitive function except language and attention, and the former group also had lower serum levels of S100B. Besides, serum S100B levels were lower in the type 2 diabetes patients with impaired cognition than in those with normal cognition. In addition, the moderate to severe cognitive impairment group had significantly lower levels than that in mild cognitive impairment group. After adjusting for confounding factors, serum S100B levels were positively correlated with cognitive function in type 2 diabetes patients.
CONCLUSIONS
Serum S100B levels were positively correlated with cognitive function in type 2 diabetes patients with cognitive impairment. It is suggested that S100B may be involved in the occurrence and development of cognitive dysfunction in type 2 diabetes patients and play a protective role.
METHODS
The clinical data and biochemical indexes of ninety-six patients with type 2 diabetes and sixty-eight healthy subjects were collected. The levels of serum S100B were detected by enzyme-linked immunosorbent assay. Ninety-six type 2 diabetes patients were divided into a cognitive dysfunction group and a normal cognition group according to Mini-mental State Examination scores. To better understand the differences in various aspects of cognition, we used the Repeatable Battery for the Assessment of Neuropsychological Status scale for further evaluation. To study the relationship between serum S100B levels and cognitive impairment, the cognitive dysfunction group was divided into a mild cognitive impairment group and a moderate to severe cognitive impairment group for further study.
目的
先前的研究已经提供了强有力的证据表明，2 型糖尿病患者存在认知障碍。S100B 在阿尔茨海默病等多种神经退行性疾病中的预测作用与认知功能密切相关。本研究旨在探讨 2 型糖尿病患者血清 S100B 水平与认知功能的相关性。
结果
除语言和注意力外，2 型糖尿病组在认知功能的所有领域的评分均低于健康对照组，且前者的血清 S100B 水平也较低。此外，认知障碍的 2 型糖尿病患者的血清 S100B 水平低于认知正常的患者。此外，中重度认知障碍组的水平明显低于轻度认知障碍组。调整混杂因素后，血清 S100B 水平与 2 型糖尿病患者的认知功能呈正相关。
结论
血清 S100B 水平与认知障碍的 2 型糖尿病患者的认知功能呈正相关。提示 S100B 可能参与 2 型糖尿病患者认知功能障碍的发生发展，发挥保护作用。
方法
收集 96 例 2 型糖尿病患者和 68 例健康受试者的临床资料和生化指标。采用酶联免疫吸附法检测血清 S100B 水平。96 例 2 型糖尿病患者根据简易精神状态检查评分分为认知功能障碍组和认知正常组。为了更好地了解认知各方面的差异，我们使用重复性成套神经心理状况评估量表进行进一步评估。为了研究血清 S100B 水平与认知障碍的关系，将认知功能障碍组分为轻度认知障碍组和中重度认知障碍组进行进一步研究。
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