Kordower J H, Gash D M
Department of Anatomy and Cell Biology, University of Illinois School of Medicine.
Neurobiol Aging. 1988 Sep-Dec;9(5-6):685-9. doi: 10.1016/s0197-4580(88)80132-5.
The relative value of animals with memory impairments, due either to experimental lesions or aging processes, is dependent upon the specific hypothesis being tested. The experimental approaches described in the preceding reviews are valuable for basic studies on learning and memory in the mammalian brain. However, because of important differences between available model systems and human disease states, such as Alzheimer's disease, their use at present may be insufficient for understanding and developing treatment strategies for human cognitive dysfunctions. In this commentary, different aspects of animal models of memory dysfunction will be discussed relative to their ability to assess the structural and functional consequences of central nervous system (CNS) repair.
因实验性损伤或衰老过程而出现记忆障碍的动物的相对价值，取决于所检验的特定假设。前述综述中描述的实验方法对于哺乳动物大脑学习和记忆的基础研究很有价值。然而，由于现有模型系统与人类疾病状态（如阿尔茨海默病）之间存在重要差异，目前使用这些模型可能不足以理解和制定针对人类认知功能障碍的治疗策略。在这篇评论中，将讨论记忆功能障碍动物模型的不同方面与其评估中枢神经系统（CNS）修复的结构和功能后果的能力的相关性。
