Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People's Republic of China.
Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People's Republic of China.
Clin Chim Acta. 2020 Jun;505:136-140. doi: 10.1016/j.cca.2020.02.029. Epub 2020 Feb 26.
This study aimed to assess the role of fibrinogen (Fib) to albumin (ALB) ratio (FAR) in ankylosing spondylitis (AS) and its association with disease activity.
135 AS patients and 76 age - and gender - matched healthy controls were collected in this retrospective study. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was used to divide the AS patients into remission group (BASDAI < 4) and active group (BASDAI ≥ 4). The association between FAR and BASDAI was evaluated by Spearman correlation. Receiver operating characteristic (ROC) curve was made to determine the area under curve (AUC) value. The prognostic value of FAR in the AS disease activity was tested by multivariate logistical regression analyses.
AS patients showed higher FAR levels than the controls (P < 0.001). FAR was also increased in active group of AS patients than those in inactive group (P < 0.001). Spearman analyses showed that FAR was positively related with BASDAI (r = 0.594, P < 0.001) in AS patients. ROC curve analyses revealed that the AUC of FAR was higher than ALB and Fib. In addition, the optimal cutoff value of FAR for AS diagnosis was 78.84, with a specificity of 88.2% and sensitivity of 77.0%. Logistical regression analyses showed that FAR (odds ratio = 13.091, 95% confidence interval: 4.686-36.571, P < 0.001) was a predictor for AS disease activity.
FAR was increased in AS and may act as a novel inflammatory parameter for mirroring disease activity in AS.
本研究旨在评估纤维蛋白原（Fib）与白蛋白（ALB）比值（FAR）在强直性脊柱炎（AS）中的作用及其与疾病活动度的关系。
本回顾性研究纳入了 135 例 AS 患者和 76 名年龄和性别匹配的健康对照者。采用 Bath 强直性脊柱炎疾病活动指数（BASDAI）评分将 AS 患者分为缓解组（BASDAI<4）和活动组（BASDAI≥4）。采用 Spearman 相关分析评估 FAR 与 BASDAI 的相关性。绘制受试者工作特征（ROC）曲线，确定曲线下面积（AUC）值。采用多变量逻辑回归分析检验 FAR 在 AS 疾病活动中的预测价值。
AS 患者的 FAR 水平高于对照组（P<0.001）。活动组 AS 患者的 FAR 水平高于非活动组（P<0.001）。Spearman 分析显示，FAR 与 AS 患者的 BASDAI 呈正相关（r=0.594，P<0.001）。ROC 曲线分析显示，FAR 的 AUC 高于 ALB 和 Fib。此外，FAR 诊断 AS 的最佳截断值为 78.84，特异性为 88.2%，敏感性为 77.0%。Logistic 回归分析显示，FAR（比值比=13.091，95%置信区间：4.686-36.571，P<0.001）是 AS 疾病活动的预测因子。
FAR 在 AS 中升高，可能作为反映 AS 疾病活动的新型炎症参数。
