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在一家区级医院设立血流动力学室、冠心病监护病房及开展直接经皮冠状动脉腔内血管成形术项目对急性冠脉综合征预后的影响

Impact of creating a haemodynamics room, a coronary unit and a primary angioplasty programme on the prognosis of acute coronary syndrome in a district hospital.

作者信息

Solís-Marquínez M N, Rondán-Murillo J J, Pérez-Otero M, Vegas-Valle J M, Lozano Martínez-Luengas Í, Morís-de la Tassa J

机构信息

Servicio de Medicina Interna, Hospital Universitario de Cabueñes, Gijón, España.

Servicio de Cardiología, Hospital Universitario de Cabueñes, Gijón, España.

出版信息

Rev Clin Esp. 2021 Apr;221(4):187-197. doi: 10.1016/j.rce.2019.11.015. Epub 2020 Feb 26.

DOI:10.1016/j.rce.2019.11.015
PMID:32113647
Abstract

OBJECTIVE

This work aims to analyze the prognosis and mortality of patients hospitalized for acute coronary syndrome before and after the implementation of a coronary care unit, hemodynamics room, and the Código Corazón [Infarction Code] primary angioplasty program METHODS: We conducted an observational, retrospective study that analyzed the epidemiological characteristics, reperfusion strategies, adverse cardiovascular events, and mortality over a follow-up period of five years. The results from the post-code period (March 1 - December 31, 2012; n=471) were compared with those from the pre-code period (March 1 - December 31, 2009; n=432).

RESULTS

There were no differences in the baseline characteristics of the two groups. However, an increase in ST-elevation acute coronary syndrome (STE-ACS) from 17.6% to 34.8% (p<.001) was observed during the postcode phase. The use of percutaneous coronary intervention was made widespread at the hospital and was used in 64.8% of non-ST-elevation acute coronary syndrome (NSTE-ACS) cases and in 95.5% of STE-ACS cases. A reduction was observed in readmissions (from 38.2% to 25.1% for NSTE-ACS (p=.001) and from 23.7% to 11.0% for STE-ACS (p=.018)), the composite prognostic variable of adverse cardiovascular events and 5-year mortality (from 58.7% to 45% (p=.001) for NSTE-ACS and from 40.8% to 23.8% (p=.009) for STE-ACS), and a decrease in 30-day mortality in STE-ACS (from 11.8% to 3.7%; p=.021).

CONCLUSIONS

With the structural changes in the hospital, the use of percutaneous coronary intervention was made widespread and improved the prognosis of patients with acute coronary syndrome, decreasing admissions, adverse cardiovascular events and mortality.

摘要

目的

本研究旨在分析在设立冠心病监护病房、血流动力学检查室以及实施“心脏梗死编码”[Infarction Code] 直接冠状动脉成形术计划前后,因急性冠状动脉综合征住院患者的预后及死亡率。方法:我们开展了一项观察性回顾性研究,分析了五年随访期内的流行病学特征、再灌注策略、不良心血管事件及死亡率。将编码实施后时期(2012年3月1日至12月31日;n = 471)的结果与编码实施前时期(2009年3月1日至12月31日;n = 432)的结果进行比较。

结果

两组的基线特征无差异。然而,在编码实施后阶段,ST段抬高型急性冠状动脉综合征(STE-ACS)的比例从17.6%增至34.8%(p <.001)。经皮冠状动脉介入治疗在该医院得到广泛应用,用于64.8%的非ST段抬高型急性冠状动脉综合征(NSTE-ACS)病例和95.5%的STE-ACS病例。再次入院率降低(NSTE-ACS从38.2%降至25.1%(p =.001),STE-ACS从23.7%降至11.0%(p =.018)),不良心血管事件的综合预后变量及5年死亡率降低(NSTE-ACS从58.7%降至45%(p =.001),STE-ACS从40.8%降至23.8%(p =.009)),STE-ACS的30天死亡率降低(从11.8%降至3.7%;p =.021)。

结论

随着医院结构的改变,经皮冠状动脉介入治疗得到广泛应用,改善了急性冠状动脉综合征患者的预后,降低了入院率、不良心血管事件及死亡率。

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