使用FlexLab模块三步两锅法自动生产NCA [F]FDOPA
Three-step two-pot automated production of NCA [F]FDOPA with FlexLab module.
作者信息
Huang Ya-Yao, Poniger Stan, Tsai Chia-Ling, Tochon-Danguy Henri J, Ackermann Uwe, Yen Ruoh-Fang
机构信息
PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan.
Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia; iPHASE Technologies, 3 Cypress Ave, Glen Waverley, Victoria, 3150, Australia.
出版信息
Appl Radiat Isot. 2020 Apr;158:108871. doi: 10.1016/j.apradiso.2019.108871. Epub 2019 Aug 22.
Automated three-step two-pot production of no-carrier-added (NCA) [F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.
无载体添加（NCA）[F]FDOPA的自动化三步两釜生产首次在iPHASE FlexLab模块中实现。用该方法合成的[F]FDOPA经衰变校正后的放射化学产率（RCY）为10%至14%（n = 7），合成时间约为110分钟，[F]FDOPA的放射化学纯度>95%，摩尔活度约为431 GBq/μmol。随着该方法在商业FlexLab模块上成功实施及其内置的逐步活度监测，将实现进一步的工艺优化。
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