Department of Internal Medicine, University Hospital of Salamanca-IBSAL, Salamanca, Spain.
Department of Parasitology-Mycology, Toulouse University Hospital, Toulouse France; Centre for Physiopathology of Toulouse-Purpan (CPTP), University of Toulouse, CNRS, INSERM, UPS, Toulouse, France.
Med Mal Infect. 2020 Jun;50(4):372-376. doi: 10.1016/j.medmal.2020.01.014. Epub 2020 Feb 27.
To describe the epidemiological, clinical and microbiological characteristics and mortality of patients with Candida bloodstream infection and systemic autoimmune diseases.
We performed a retrospective multicenter study of candidemia in adults with systemic autoimmune diseases between 2010 and 2016.
Among 1040 patients with candidemia, 36 (3.5%) had a systemic autoimmune disease. The most common systemic autoimmune disease was rheumatoid arthritis (27.8%). The most common species was Candida albicans (66.7%). Twenty-two (61.1%) patients received a corticosteroid therapy and nine (25%) received an immunosuppressive therapy at the time of candidemia. The mortality rate was 27.8%.
Systemic autoimmune diseases are not common in patients with candidemia. The unadjusted mortality rate was comparable to other candidemia studies in the general population.
描述伴有系统性自身免疫性疾病的念珠菌血流感染患者的流行病学、临床和微生物学特征及死亡率。
我们进行了一项回顾性多中心研究，纳入了 2010 年至 2016 年期间患有系统性自身免疫性疾病的成人念珠菌血症患者。
在 1040 例念珠菌血症患者中，36 例（3.5%）患有系统性自身免疫性疾病。最常见的系统性自身免疫性疾病是类风湿关节炎（27.8%）。最常见的菌种是白色念珠菌（66.7%）。22 例（61.1%）患者在发生念珠菌血症时接受了皮质类固醇治疗，9 例（25%）患者接受了免疫抑制治疗。死亡率为 27.8%。
系统性自身免疫性疾病在念珠菌血症患者中并不常见。未经调整的死亡率与一般人群中其他念珠菌血症研究相当。
Zotero 插件