Epidemiological Characteristics, Antifungal Susceptibility, Risk Factors, and Outcomes of Bloodstream Infection: A Ten-Year Surveillance in a Teaching Hospital in China.

BACKGROUND

is one of the most important pathogens of hospital-acquired bloodstream infections. Its morbidity and mortality are still high, which is a serious global public problem.

PURPOSE

To investigate the strain distribution, drug susceptibility, clinical characteristics of patients, and risk factors affecting the prognosis of bloodstream infection (BSI).

MATERIALS AND METHODS

We retrospectively collected the clinical data, infection-related indicators, prognosis, strain prevalence and drug susceptibility of 163 patients with BSI in a teaching hospital from January 2012 to December 2022. Univariate and multivariate logistic regression were used to analyze the risk factors affecting the prognosis.

RESULTS

In 163 cases of BSI, accounted for 48.47%, and non accounted for 51.53%. A total of 163 patients with BSI were mainly distributed in intensive care unit (ICU) and emergency department, accounting for 40.49% and 14.72%, respectively. The resistance rate of to fluconazole, itraconazole and voriconazole was less than 10%, and the sensitivity rate of to fluconazole, itraconazole and voriconazole was less than 80%. The mortality rate of 163 patients with BSI was 33.13%, with non- higher than that of ( = 0.04). Multivariate analysis showed that hemodialysis (OR = 0.199, 95% CI: 0.059-0.673, = 0.009), arteriovenous catheters (OR = 0.344, 95% CI: 0.130-0.913, = 0.032), elevated neutrophil count (OR = 0.409, 95% CI: 0.194-0.862, = 0.019) and APACHE II score ( = 0.848, 95% CI: 0.789~0.911, < 0.001) were independent risk factors for death in patients with candidemia.

CONCLUSION

The blood flow infection rate of non- is increasing, and the mortality rate and resistance to antifungal drugs are higher than that of . Hemodialysis, arteriovenous catheters, elevated neutrophil count and APACHE II score were associated with death in patients with BSI.