School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Int J Biol Macromol. 2020 Jun 1;152:456-464. doi: 10.1016/j.ijbiomac.2020.02.309. Epub 2020 Feb 27.
In this work, a low-cost and sustainable non-animal chitin from Hericium erinaceus residue was used to prepare hydrogels through a facile procedure. The chitin was firstly dissolved in NaOH/Urea aqueous solution by freeze thawing, and then the obtained chitin solution was directly regenerated to form hydrogels. The results showed that the extracted chitin could dissolve in NaOH/urea solvent system. The chitin solutions with concentrations from 1% to 4% showed no gelation behavior, while those with concentrations from 5% to 7% could form hydrogels. The obtained hydrogels showed elastic characteristic and desirable transmittance. In addition, the hydrogels with higher chitin concentration exhibited more compact gel network and improved gel strength, but decreased swelling degree and cumulative drug release. Compared with neat chitin, the thermal stability of the regenerated chitin hydrogels was also improved. The 5-Fu could be gradually released from the hydrogels, which followed Fickian diffusion model.
在这项工作中，使用一种低成本且可持续的来自珊瑚菌废渣的非动物甲壳素，通过简单的方法制备水凝胶。甲壳素首先通过冻融溶解在 NaOH/Urea 水溶液中，然后将得到的甲壳素溶液直接再生形成水凝胶。结果表明，提取的甲壳素可以溶解在 NaOH/尿素溶剂体系中。浓度为 1%至 4%的甲壳素溶液没有凝胶化行为，而浓度为 5%至 7%的溶液可以形成水凝胶。所得到的水凝胶具有弹性特征和理想的透光率。此外，具有较高甲壳素浓度的水凝胶表现出更致密的凝胶网络和更高的凝胶强度，但溶胀度和累积药物释放降低。与纯甲壳素相比，再生甲壳素水凝胶的热稳定性也得到了提高。5-Fu 可以从水凝胶中逐渐释放，遵循菲克扩散模型。
