National Institute of Biomedical Genomics, Kalyani, WB, India.
National Institute of Biomedical Genomics, Kalyani, WB, India,
Front Biosci (Landmark Ed). 2020 Mar 1;25(5):961-978. doi: 10.2741/4843.
Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression. CAFs establish communication with cancer cells through paracrine mechanisms or via direct cell adhesion as well as influence the cancer cell behaviour indirectly by remodelling the extracellular matrix. Although numerous studies have strongly suggested the tumor promoting role of CAFs, few recent reports have revealed the heterogeneity in CAFs. Here, we have summarized the recent findings on the mechanisms related to the heterogeneous behaviour of CAFs serving as positive or negative regulator of tumor progression. Further, reports related to the targeted therapy against CAF-mediated mechanisms are also summarized briefly.
癌症相关成纤维细胞（CAFs）是实体瘤微环境（TME）中最丰富的基质细胞类型，已成为肿瘤进展的关键参与者。CAFs 通过旁分泌机制或通过直接细胞黏附与癌细胞建立通讯，并通过重塑细胞外基质间接影响癌细胞行为。尽管许多研究强烈表明 CAFs 具有促进肿瘤的作用，但最近的报道很少揭示 CAFs 的异质性。在这里，我们总结了与 CAFs 异质性行为相关的机制的最新发现，这些机制可作为肿瘤进展的正调节剂或负调节剂。此外，还简要总结了与针对 CAF 介导的机制的靶向治疗相关的报告。
