载脂蛋白基因多态性与多囊卵巢综合征易感性的关系：系统评价和荟萃分析。
Association of Paraoxonase 1 Gene Polymorphisms and Polycystic Ovarian Syndrome Susceptibility: A Systematic Review and Meta-Analysis.
机构信息
Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, Hangzhou, China.
Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, Hangzhou, China,
出版信息
Gynecol Obstet Invest. 2020;85(2):167-177. doi: 10.1159/000505452. Epub 2020 Feb 28.
INTRODUCTION
The goal of this study was to review relevant case-control trials in order to determine the association of paraoxonase 1 (PON1) gene polymorphisms (-108C/T, 55L/M, 192Q/R) and polycystic ovarian syndrome (PCOS) susceptibility.
METHODS
Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP. Key pertinent sources in the literature were also reviewed, and all articles published through April 2019 were considered for inclusion. Based on the qualified studies, we performed a meta-analysis of associations between -108C/T, 55L/M and 192Q/R polymorphisms in PON1 and risk of PCOS.
RESULTS
We included 13 case-control studies with 3,660 total patients in the PCOS group and 2,835 in the control group. These studies found that the population with -108C/T locus T were associated with lower PCOS susceptibility by heterozygote model (OR 0.442, 95% CI 0.259-0.754); the Caucasian population with -108C/T locus T were associated with higher PCOS susceptibility by regressive model (OR 2.087, 95% CI 1.242-3.504). The population with 55L/M locus M were associated with higher PCOS susceptibility by regressive model (OR 1.518, 95% CI 1.067-2.160); the Asian population with 55L/M locus M were associated with lower PCOS susceptibility by dominant model and heterozygote model. The population with 192Q/R locus R were associated with higher PCOS susceptibility by the 5 gene models. The Asian population with 192Q/R locus R were associated with higher PCOS susceptibility: allelic model (OR 1.271, 95% CI 1.139-1.417); homozygote model (OR 1.575, 95% CI 1.244-1.995); dominant model (OR 1.299, 95% CI 1.069-1.580); regressive model (OR 1.421, 95% CI 1.207-1.673). The Caucasian population with 192Q/R locus R were associated with higher PCOS susceptibility: heterozygote model (OR 2.113, 95% CI 1.266-3.526).
CONCLUSION
Our meta-analysis suggested that 192Q/R locus R were associated with higher PCOS susceptibility in both the Asian and Caucasian population.
简介
本研究旨在通过回顾相关的病例对照试验，确定对氧磷酶 1（PON1）基因多态性（-108C/T、55L/M、192Q/R）与多囊卵巢综合征（PCOS）易感性的相关性。
方法
使用合适的关键词，我们通过 PubMed、Cochrane、Embase、CNKI、VANFUN 和 VIP 等数据库检索了相关研究。还对文献中的关键来源进行了综述，考虑了截至 2019 年 4 月发表的所有文章。基于合格的研究，我们对 PON1 中的-108C/T、55L/M 和 192Q/R 多态性与 PCOS 风险之间的关联进行了荟萃分析。
结果
我们纳入了 13 项病例对照研究，其中 PCOS 组共 3660 例患者，对照组共 2835 例患者。这些研究发现，-108C/T 位点 T 等位基因携带者的人群患 PCOS 的风险较低，杂合子模型（OR 0.442，95%CI 0.259-0.754）；-108C/T 位点 T 等位基因携带者的白种人群患 PCOS 的风险较高，回归模型（OR 2.087，95%CI 1.242-3.504）。55L/M 位点 M 等位基因携带者的人群患 PCOS 的风险较高，回归模型（OR 1.518，95%CI 1.067-2.160）；55L/M 位点 M 等位基因携带者的亚洲人群患 PCOS 的风险较低，显性模型和杂合子模型。192Q/R 位点 R 等位基因携带者的人群患 PCOS 的风险较高，5 种基因模型。亚洲人群中 192Q/R 位点 R 等位基因携带者患 PCOS 的风险较高：等位基因模型（OR 1.271，95%CI 1.139-1.417）；纯合子模型（OR 1.575，95%CI 1.244-1.995）；显性模型（OR 1.299，95%CI 1.069-1.580）；回归模型（OR 1.421，95%CI 1.207-1.673）。白种人群中 192Q/R 位点 R 等位基因携带者患 PCOS 的风险较高：杂合子模型（OR 2.113，95%CI 1.266-3.526）。
结论
我们的荟萃分析表明，192Q/R 位点 R 与亚洲和白种人群的 PCOS 易感性有关。
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