Xue Rui-Hong, Li Juan, Huang Zhen, Li Zheng-Zheng, Chen Lei, Lin Qin, Huang He-Feng
Department of Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Pathology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Arch Gynecol Obstet. 2020 Mar;301(3):721-727. doi: 10.1007/s00404-020-05465-x. Epub 2020 Feb 29.
To investigate whether there are left-right asymmetries in tubal endometriosis and the factors affecting this predisposition.
Women who underwent salpingectomy for gynecological diseases and were diagnosed with tubal endometriosis between January 2002 and July 2019 were included in the study. The frequencies of left and right tubal endometriosis were compared with the expected 50% using a binominal test. The demographic characteristics and presence of ovarian endometrioid cysts, adenomyosis, and hydrosalpinx were also analyzed.
During the study period of more than 17 years, 305 women were diagnosed with tubal endometriosis. The distribution of tubal endometriosis in the left or right fallopian tubes was analyzed. Tubal endometriosis was found in the left fallopian tube in 168 (55.08%) women, in the right fallopian tube in 93 (30.49%), and bilaterally in 44 (14.43%). Left unilateral tubal endometriosis was found most frequently (64.37%, 168/261), and its incidence was significantly higher than 50% (P < 0.001, binominal test). Furthermore, the frequency of left ovarian endometrioid cysts (58.82%) was higher than that of right ovarian endometrioid cysts (41.18%) (P < 0.001, binominal test).
Our study confirms that tubal endometriosis is a left-side asymmetric disease, and this predisposition is highly consistent with ovarian endometrioid cysts, which supports the transplantation theory of the origin of endometriosis.
探讨输卵管子宫内膜异位症是否存在左右不对称性以及影响这种易感性的因素。
纳入2002年1月至2019年7月因妇科疾病行输卵管切除术并被诊断为输卵管子宫内膜异位症的女性。采用二项式检验将左右输卵管子宫内膜异位症的发生率与预期的50%进行比较。还分析了人口统计学特征以及卵巢子宫内膜样囊肿、子宫腺肌病和输卵管积水的存在情况。
在超过17年的研究期间，305名女性被诊断为输卵管子宫内膜异位症。分析了输卵管子宫内膜异位症在左、右输卵管中的分布情况。168名（55.08%）女性的左侧输卵管发现有输卵管子宫内膜异位症，93名（30.49%）女性的右侧输卵管发现有该病症，44名（14.43%）女性双侧均有。左侧单侧输卵管子宫内膜异位症最为常见（64.37%，168/261），其发生率显著高于50%（二项式检验，P < 0.001）。此外，左侧卵巢子宫内膜样囊肿的发生率（58.82%）高于右侧卵巢子宫内膜样囊肿（41.18%）（二项式检验，P < 0.001）。
我们的研究证实输卵管子宫内膜异位症是一种左侧不对称性疾病，这种易感性与卵巢子宫内膜样囊肿高度一致，这支持了子宫内膜异位症起源的移植理论。
