Li Y X, Wu W, Yang T, Zhou W, Fu Y M, Feng Q M, Ye J M
Emergency Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital (The Sixth People's Hospital) , Shanghai200233, China.
Emergency Department, Jinshan Branch of The Sixth People's Hospital of Shanghai, Shanghai 201599, China.
Zhonghua Nei Ke Za Zhi. 2020 Mar 1;59(0):E003.
To investigate the early changes of peripheral blood leukocyte differential counts in patients with COVID-19. Ten patients with COVID-19 and 30 patients with other viral pneumonia (non-COVID-19) admitted to Shanghai Jiao Tong University Affiliated Sixth People's Hospital and Jinshan Branch Hospital from January 22 to February 17, 2020 were enrolled in this study. The differential counts of white blood cells were analyzed. Patients in COVID-19 group showed relatively lower absolute white blood cell (WBC) count 4.95(3.90,6.03)×10(9)/L, lymphocyte absolute count 1.20(0.98,1.50)×10(9)/L and eosinophil absolute count 0.01(0.01,0.01)×10(9)/L. Leukopenia developed in two patients(2/10), lymphocytopenia also in two patients(2/10). Seven over ten patients presented with eosinophil cytopenia. In non-COVID-19 group, absolute WBC count was 8.20 (6.78,9.03) ×10(9)/L (<0.001), lymphocyte absolute count 1.75(1.20,2.53)×10(9)/L(=0.036), eosinophil absolute count 0.02(0.01,0.03)×10(9)/L(=0.05). Lymphocytopenia occurred in (16.7%) patients, eosinophil cytopenia in 16.7% patients too. In conclusion, leukopenia, lymphocytopenia and eosinophil cytopenia are more common in COVID-19 patients than those in non- COVID-19 patients.
为研究新型冠状病毒肺炎（COVID-19）患者外周血白细胞分类计数的早期变化。选取2020年1月22日至2月17日在上海交通大学附属第六人民医院及金山分院收治的10例COVID-19患者和30例其他病毒性肺炎（非COVID-19）患者纳入本研究。分析白细胞分类计数情况。COVID-19组患者白细胞绝对计数相对较低，为4.95（3.90，6.03）×10⁹/L，淋巴细胞绝对计数为1.20（0.98，1.50）×10⁹/L，嗜酸性粒细胞绝对计数为0.01（0.01，0.01）×10⁹/L。2例患者出现白细胞减少（2/10），2例患者出现淋巴细胞减少（2/10）。十分之七的患者出现嗜酸性粒细胞减少。在非COVID-19组中，白细胞绝对计数为8.20（6.78，9.03）×10⁹/L（<0.001），淋巴细胞绝对计数为1.75（1.20，2.53）×10⁹/L（=0.036），嗜酸性粒细胞绝对计数为0.02（0.01，0.03）×10⁹/L（=0.05）。（16.7%）的患者出现淋巴细胞减少，16.7%的患者也出现嗜酸性粒细胞减少。综上所述，COVID-19患者中白细胞减少、淋巴细胞减少和嗜酸性粒细胞减少比非COVID-19患者更常见。
