Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria.
Department of Pediatric Neurology, Children's Hospital Datteln, University of Witten Herdecke, Germany.
Eur J Paediatr Neurol. 2020 May;26:29-33. doi: 10.1016/j.ejpn.2020.02.006. Epub 2020 Feb 20.
To analyze the association between pubertal stage, menstrual cycle and migraine attacks in girls with migraine. In addition, headache frequency, accompanying symptoms, duration and onset in relation to the specific phase of the cycle were investigated.
Girls between 7 and 18 years old, diagnosed with headaches that met "International Classification of Headache Disorders II" diagnostic criteria for migraine without aura, kept a daily headache and menstrual cycle diary over 8 weeks. Ovulatory cycles were identified by weekly progesterone saliva tests.
47 girls participated in the study and were divided into three groups according to Tanner stage and onset of regular menstruation: pre- (n = 16), peri- (n = 19) and post-pubertal (n = 12). A significant difference in migraine frequency was found between pre- and post-pubertal girls (p = 0.005). No significant differences with regard to headache characteristics were detected. Interestingly, a higher frequency of attacks in follicular phase occurred compared to luteal phase in peri- and post-pubertal girls (p = 0.030).
During puberty, migraine patterns in girls change to a typical adult pattern of migraine in a stepwise manner not clearly related to menarche. The first sign of this transition phase could be the higher frequency of migraine attacks in post-pubertal girls.
分析青春期阶段、月经周期与偏头痛发作在偏头痛女孩中的相关性。此外，还调查了头痛频率、伴随症状、持续时间和发作与周期特定阶段的关系。
7 至 18 岁的女孩，患有符合无先兆偏头痛的“国际头痛疾病分类第二版”诊断标准的头痛，在 8 周内每天记录头痛和月经周期日记。通过每周孕激素唾液测试确定排卵周期。
47 名女孩参与了研究，并根据 Tanner 阶段和规律月经的开始分为三组：青春期前（n=16）、青春期（n=19）和青春期后（n=12）。青春期前和青春期后女孩的偏头痛发作频率存在显著差异（p=0.005）。在头痛特征方面未发现显著差异。有趣的是，青春期和青春期后女孩的卵泡期发作频率高于黄体期（p=0.030）。
在青春期，女孩的偏头痛模式逐渐转变为典型的成人偏头痛模式，与初潮无明显关系。这个过渡阶段的第一个迹象可能是青春期后女孩偏头痛发作的频率更高。
