基于胶束增敏荧光猝灭的荧光传感器用于血清中非转铁蛋白结合铁的高灵敏检测。
A micellized fluorescence sensor based on amplified quenching for highly sensitive detection of non-transferrin-bound iron in serum.
机构信息
Department of Chemistry and Institute of Natural Sciences, Daegu University, Gyeongsan 38453, Republic of Korea.
出版信息
Dalton Trans. 2020 Apr 15;49(15):4660-4664. doi: 10.1039/d0dt00026d.
PMID:32115591
Abstract
A novel, micelle-based fluorescence system capable of selective and sensitive signal transduction for non-transferrin-bound iron (NTBI) in serum was devised. We demonstrated that an aggregated fluorogenic core in a micelle induces amplified fluorescence quenching, which differentiates this sensing platform from the numerous fluorescence-based tools previously developed for sensitive detection.
摘要
设计了一种新颖的基于胶束的荧光系统，能够对血清中非转铁蛋白结合铁（NTBI）进行选择性和灵敏的信号转导。我们证明了胶束中聚集的荧光核心诱导放大的荧光猝灭，这使该传感平台与之前开发的用于灵敏检测的众多基于荧光的工具区分开来。
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