Custodio-Chablé Santiago J, Lezama Ruth A, Reyes-Maldonado Elba
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
Cir Cir. 2020;88(2):233-243. doi: 10.24875/CIRU.19000725.
Platelets, in addition to participating in atherosclerosis, play a very active role in the immune response of this disease since they have the ability to interact with various inflammatory cells, in addition to secreting cytokines, chemokines, growth factors, etc. The functions of platelets go beyond their interaction with the endothelium, as they participate in creating an inflammatory environment, which contributes to the loss of homeostasis. On the other hand, platelet-derived microparticles induce the activation of other platelets, of endothelial cells and in recruiting leukocytes. For all the above, platelets and the inflammatory environment can be considered as possible therapeutic targets to prevent the development of atherosclerosis and the events associated with it.
血小板除了参与动脉粥样硬化外，在该疾病的免疫反应中也发挥着非常积极的作用，因为它们不仅能够与各种炎症细胞相互作用，还能分泌细胞因子、趋化因子、生长因子等。血小板的功能不仅限于与内皮细胞的相互作用，它们还参与营造炎症环境，这会导致体内平衡的丧失。另一方面，血小板衍生的微粒可诱导其他血小板、内皮细胞的活化以及白细胞的募集。基于上述所有原因，血小板和炎症环境可被视为预防动脉粥样硬化及其相关事件发生的潜在治疗靶点。
