Giannoni Patrizia, Claeysen Sylvie, Noe Francesco, Marchi Nicola
Laboratoire CHROME (EA 7352), Université de Nîmes, Nîmes, France.
CNRS, INSERM U1191, Institut de Génomique Fonctionnelle, University of Montpellier, Montpellier, France.
Front Aging Neurosci. 2020 Feb 4;12:3. doi: 10.3389/fnagi.2020.00003. eCollection 2020.
A bidirectional crosstalk between peripheral players of immunity and the central nervous system (CNS) exists. Hence, blood-brain barrier (BBB) breakdown is emerging as a participant mechanism of dysregulated peripheral-CNS interplay, promoting diseases. Here, we examine the implication of BBB damage in neurodegeneration, linking it to peripheral brain-directed autoantibodies and gut-brain axis mechanisms. As BBB breakdown is a factor contributing to, or even anticipating, neuronal dysfunction(s), we here identify contemporary pharmacological strategies that could be exploited to repair the BBB in disease conditions. Developing neurovascular, add on, therapeutic strategies may lead to a more efficacious pre-clinical to clinical transition with the goal of curbing the progression of neurodegeneration.
免疫外周参与者与中枢神经系统（CNS）之间存在双向串扰。因此，血脑屏障（BBB）破坏正成为外周与中枢神经系统相互作用失调、促进疾病发生的一种参与机制。在此，我们研究了BBB损伤在神经退行性变中的影响，将其与外周脑靶向自身抗体和肠脑轴机制联系起来。由于BBB破坏是导致甚至预示神经元功能障碍的一个因素，我们在此确定了可用于在疾病状态下修复BBB的当代药理学策略。开发神经血管附加治疗策略可能会带来更有效的临床前到临床的转化，以抑制神经退行性变的进展。
