Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an 710032, China.
Department of Neurosurgery, PLA 163rd Hospital (Second Affiliated Hospital of Hunan Normal University), Changsha 410000, China.
Int J Biol Sci. 2021 Jan 1;17(1):368-378. doi: 10.7150/ijbs.52169. eCollection 2021.
Traumatic brain injury (TBI) is recognized as the disease with high morbidity and disability around world in spite of the work ongoing in neural protection. Due to heterogeneity among the patients, it's still hard to acquire satisfying achievements in clinic. Neuroinflammation, which exists since primary injury occurs, with elusive duality, appear to be of significance from recovery of injury to neurogenesis. In recent years, studied have revealed that communication in neurogenic niche is more than "cell to cell" communication, and study on NSCs represent it as central role in the progress of neural regeneration. Hence, the neuroinflammation-affecting crosstalk after TBI, and clarifying definitive role of NSCs in the course of regeneration is a promising subject for researchers, for its great potential in overcoming the frustrating status quo in clinic, promoting welfare of TBI patient.
创伤性脑损伤（TBI）是一种全球性高发病率和高致残率的疾病，尽管在神经保护方面正在进行研究。由于患者之间存在异质性，临床上仍难以取得满意的效果。神经炎症自原发性损伤发生后就存在，具有难以捉摸的双重性，从损伤恢复到神经发生，神经炎症似乎都具有重要意义。近年来的研究表明，神经发生龛中的通讯不仅仅是“细胞间”通讯，神经干细胞的研究表明其在神经再生过程中起着核心作用。因此，TBI 后神经炎症影响的串扰，以及明确神经干细胞在再生过程中的确切作用，是研究人员的一个有前途的课题，因为它有可能克服临床上令人沮丧的现状，促进 TBI 患者的福利。
