静脉注射后一名志愿者体内阿替卡因的临床效果及药代动力学
Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration.
作者信息
Van Oss G E, Vree T B, Baars A M, Termond E F, Booij L H
机构信息
Department of Anaesthesiology, Hervormd Diaconessenhuis, Arnhem, The Netherlands.
出版信息
Pharm Weekbl Sci. 1988 Dec 9;10(6):284-6. doi: 10.1007/BF02219670.
PMID:3211703
Abstract
Articainic acid, a major metabolite of articaine, was administered to a volunteer. Since the renewed interest in the utilization of articaine in epidural anaesthesia, it has been important to assess the clinical effects of this metabolite. It was noted that articainic acid had no effect on EEG, ECG, blood pressure and heart rate. Pharmacokinetic parameters are given.
摘要
阿替卡因的主要代谢产物阿替卡因酸被给予一名志愿者。自从人们对阿替卡因在硬膜外麻醉中的应用重新产生兴趣以来，评估这种代谢产物的临床效果就变得很重要。据观察，阿替卡因酸对脑电图、心电图、血压和心率均无影响。文中给出了药代动力学参数。
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