Sun Xiaoting, Feng Xiaogang, Wu Xiaojing, Lu Yongtian, Chen Kaihong, Ye Ying
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Physiology, University of Zurich, Zurich, Switzerland.
Front Cell Dev Biol. 2020 Feb 12;8:33. doi: 10.3389/fcell.2020.00033. eCollection 2020.
Loss of body weight, especially loss of adipose tissue and skeletal muscle weight, characterizes cancer-associated cachexia (CAC). Clinically, therapeutic options for CAC are limited due to the complicated signaling between cancer and other organs. Recent research advances show that adipose tissues play a critical role during thermogenesis, glucose homeostasis, insulin sensitivity, and lipid metabolism. Understanding the adipocyte lipolysis, the formation of beige adipocytes, and the activation of brown adipocytes is vital for novel therapies for metabolic syndromes like CAC. The system-level crosstalk between adipose tissue and other organs involves adipocyte lipolysis, white adipose tissue browning, and secreted factors and metabolites. Novel CAC animal models and accumulating molecular signaling knowledge have provided mechanisms that may ultimately be translated into future therapeutic possibilities that benefit CAC patients. This mini review discusses the role of adipose tissue in CAC development, mechanism, and therapy.
体重减轻，尤其是脂肪组织和骨骼肌重量的减轻，是癌症相关性恶病质（CAC）的特征。临床上，由于癌症与其他器官之间复杂的信号传导，CAC的治疗选择有限。最近的研究进展表明，脂肪组织在产热、葡萄糖稳态、胰岛素敏感性和脂质代谢过程中发挥着关键作用。了解脂肪细胞的脂解作用、米色脂肪细胞的形成以及棕色脂肪细胞的激活对于治疗诸如CAC等代谢综合征的新疗法至关重要。脂肪组织与其他器官之间的系统水平相互作用涉及脂肪细胞脂解、白色脂肪组织褐变以及分泌因子和代谢产物。新型CAC动物模型和不断积累的分子信号知识提供了一些机制，这些机制最终可能转化为使CAC患者受益的未来治疗可能性。这篇小型综述讨论了脂肪组织在CAC发生发展、机制及治疗中的作用。
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