Wong Amanda H, Tran Thai
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Front Cell Dev Biol. 2020 Feb 7;8:64. doi: 10.3389/fcell.2020.00064. eCollection 2020.
The tetraspanin, Cluster of Differentiation 151 (CD151), is ubiquitously expressed in adult tissue, especially in the lungs where it has been implicated in lung cancer, asthma, influenza, and idiopathic pulmonary fibrosis (IPF). CD151 interacts with laminin-binding integrins and growth factor receptors, and is reported in cancer-promoting processes such as tumor initiation, metastasis, and angiogenesis. In asthma, CD151 was shown to promote airways hyperresponsiveness through calcium signaling whereas in influenza, CD151 was shown to be a novel host factor for nuclear viral export signaling. Furthermore, CD151 was shown to be associated with increased disease severity and poorer survival outcome in asthma and lung cancer, respectively. In this review, we provide an update on the current understanding of CD151 with regards to its contribution to lung pathophysiology. We also summarize factors that have been shown to regulate CD151 expression and identify key areas that need to be taken into consideration for its utility as a screening or prognostic tool in disease management and/or as a therapeutic target for the treatment of lung diseases.
四跨膜蛋白分化簇151（CD151）在成人组织中普遍表达，尤其在肺部，它与肺癌、哮喘、流感和特发性肺纤维化（IPF）有关。CD151与层粘连蛋白结合整合素和生长因子受体相互作用，并在肿瘤起始、转移和血管生成等促癌过程中发挥作用。在哮喘中，CD151通过钙信号传导促进气道高反应性，而在流感中，CD151被证明是核病毒输出信号的一种新型宿主因子。此外，CD151分别与哮喘和肺癌中疾病严重程度增加和较差的生存结果相关。在本综述中，我们提供了关于CD151对肺病理生理学贡献的当前理解的最新情况。我们还总结了已被证明调节CD151表达的因素，并确定了在疾病管理中将其用作筛查或预后工具和/或作为肺部疾病治疗靶点时需要考虑的关键领域。
