Kaplinsky C, Mor C, Cohen I J, Goshen Y, Zaizov R, Atias D
Sambur Center for Pediatric Hematology and Oncology, Petah Tikva, Israel.
Pediatr Pathol. 1988;8(4):377-84. doi: 10.3109/15513818809041571.
Cervical lymph node enlargement is probably the most frequently detected childhood lymphadenopathy. We report 2 cases of cervical lymphadenopathy in children associated with hyper-IgE and eosinophilia, displaying the features of necrotizing eosinophilic granulomatosis. Immunohistochemical analysis and a serological work-up failed to elucidate the underlying etiology. We would like to call the attention of physicians and pathologists to this unusual clinical picture, different from the fatal form of necrotizing eosinophilic granulomatosis, and we suggest a role for the eosinophils in the pathologic appearance of the lymph nodes.
颈部淋巴结肿大可能是儿童期最常被检测到的淋巴结病。我们报告2例儿童颈部淋巴结病，伴有高IgE血症和嗜酸性粒细胞增多，表现为坏死性嗜酸性肉芽肿的特征。免疫组织化学分析和血清学检查未能阐明潜在病因。我们希望引起医生和病理学家对这种不同于坏死性嗜酸性肉芽肿致死形式的不寻常临床表现的关注，并提示嗜酸性粒细胞在淋巴结病理表现中所起的作用。
