School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.
Department of Anesthesiology, The Affiliated Huaian Hospital of Xuzhou Medical University and Huaian Second People's Hospital, Huaian, China.
Laryngoscope. 2021 Jan;131(1):E63-E69. doi: 10.1002/lary.28594. Epub 2020 Mar 2.
OBJECTIVES/HYPOTHESIS: Systemic infusions of lidocaine have been widely used as perioperative analgesic adjuvants. The aim of this randomized, double-blinded, controlled trial was to investigate the effect of perioperative lidocaine infusion on postoperative early recovery quality in upper airway surgery.
Prospective, randomized, double-blinded, placebo-controlled trial.
A total of 99 patients were randomly assigned to the lidocaine group (group L) or the control group (group C). The patients received 2 mg/kg lidocaine completed within 10 minutes before the induction of anesthesia followed by continuous infusions of 2 mg/kg/hr lidocaine (group L) or the same volume of 0.9% normal saline (group C) intravenously during anesthesia. The Quality of Recovery-40 (QoR-40) survey was administered on the preoperative day (Pre) and postoperative days 1 (POD1) and 2 (POD2). The primary endpoint was QoR-40 score on POD1 and POD2.
Compared with Pre, global QoR-40 scores on POD1 and POD2 were significantly lower (P < .05). Compared with group C, global QoR-40 scores were significantly higher in group L on POD1 and POD2 (P < .05). Among the five dimensions of QoR-40, the scores for physical comfort, emotional state, and pain were superior in group L compared to group C (P < .05). Compared with group C, the consumption of remifentanil and diclofenac as well as the incidence of postoperative nausea and vomiting (PONV) and postoperative 48-hour numeric rating scale (NRS) scores in group L were significantly lower (P < .05).
Systemic lidocaine infusion can improve QoR-40 scores in patients with upper airway surgery, reduce the dosage of intraoperative opioids, decrease the incidence of PONV and NRS scores 2 days after surgery, thus improving postoperative early recovery quality.
1b Laryngoscope, 131:E63-E69, 2021.
目的/假设：局部麻醉药的全身输注已广泛用作围手术期镇痛辅助剂。本随机、双盲、对照试验的目的是研究围手术期利多卡因输注对上气道手术术后早期恢复质量的影响。
前瞻性、随机、双盲、安慰剂对照试验。
共 99 例患者随机分为利多卡因组（L 组）或对照组（C 组）。患者在麻醉诱导前 10 分钟内接受 2mg/kg 利多卡因，然后静脉输注 2mg/kg/hr 利多卡因（L 组）或相同体积的 0.9%生理盐水（C 组）。在术前日（Pre）和术后第 1 天（POD1）和第 2 天（POD2）进行 QoR-40 调查。主要终点是 POD1 和 POD2 的 QoR-40 评分。
与 Pre 相比，POD1 和 POD2 的总体 QoR-40 评分显著降低（P<0.05）。与 C 组相比，L 组 POD1 和 POD2 的总体 QoR-40 评分显著升高（P<0.05）。在 QoR-40 的五个维度中，L 组在身体舒适度、情绪状态和疼痛方面的评分均优于 C 组（P<0.05）。与 C 组相比，L 组的瑞芬太尼和双氯芬酸消耗量以及术后恶心呕吐（PONV）和术后 48 小时数字评分量表（NRS）评分的发生率均显著降低（P<0.05）。
全身利多卡因输注可改善上气道手术患者的 QoR-40 评分，减少术中阿片类药物的用量，降低术后恶心呕吐和术后 2 天 NRS 评分的发生率，从而改善术后早期恢复质量。
1b Laryngoscope, 131:E63-E69, 2021.
