青少年特发性关节炎
Juvenile Idiopathic Arthritis
作者信息
Thatayatikom Akaluck, Modica Renee, De Leucio Alessandro
机构信息
University of Florida
Hopital universitaire des enfants Reine Fabiola
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of idiopathic inflammatory arthritis affecting children younger than 16 and lasting 6 weeks or longer. The terminology of chronic arthritis in children has evolved from juvenile chronic arthritis and juvenile rheumatoid arthritis to JIA since 1995. According to the consensus conference of the International League of Associations for Rheumatology in 2001, there are 7 JIA categories: a) oligoarthritis; b) rheumatoid factor (RF) positive polyarthritis; c) RF negative polyarthritis; d) systemic arthritis; e) psoriatic arthritis; f) enthesitis-related arthritis; g) undifferentiated arthritis. These subtypes have distinct phenotypes, genetic predispositions, pathophysiology, laboratory findings, disease course, and prognosis. Although chronic arthritis is mandatory for all subtypes, the extraarticular and the systemic manifestations characterized every specific subtype. Recently, a new preliminary data-driven classification for JIA is proposed and being formally validated by the Pediatric Rheumatology International Trial Organization.
幼年特发性关节炎（JIA）是一组异质性的特发性炎性关节炎，影响16岁以下儿童，病程持续6周或更长时间。自1995年以来，儿童慢性关节炎的术语已从幼年慢性关节炎和幼年类风湿关节炎演变为JIA。根据2001年国际风湿病联盟协会共识会议，JIA有7种类型：a）少关节炎；b）类风湿因子（RF）阳性多关节炎；c）RF阴性多关节炎；d）全身型关节炎；e）银屑病关节炎；f）附着点炎相关关节炎；g）未分化关节炎。这些亚型具有不同的表型、遗传易感性、病理生理学、实验室检查结果、疾病病程和预后。虽然慢性关节炎是所有亚型的必备特征，但关节外和全身表现是每种特定亚型的特征。最近，一种新的基于数据驱动的JIA初步分类方法被提出，并正在由国际儿科风湿病试验组织进行正式验证。
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