Fraile I G, McEwen B S, Pfaff D W
Rockefeller University, New York, NY 10021.
Pharmacol Biochem Behav. 1988 Jul;30(3):729-35. doi: 10.1016/0091-3057(88)90091-3.
Progesterone can reduce aggressive behaviors in rodents under various experimental conditions, but it could be argued that this effect is due to the well known anesthetic/sedative properties of some steroids. We have tested this hypothesis by comparing the effects of progesterone and the anesthetic progestin, alphaxalone, on the aggressive, reproductive and locomotor behaviors of hamsters. Locomotion is used as a sensitive index of sedative/soporific effects. Progesterone reduced aggressive behavior without depressing the general locomotor activity of the animals, and it also facilitated feminine sexual behaviors in both sexes. Alphaxalone induced mild sedation in hamsters but this did not decrease their aggressive display. Alphaxalone did not facilitate feminine sexual behavior in either sex. We proposed that the inhibitory effect of progesterone on hamster aggressiveness is unlikely to follow from the hormone's sedative properties.
在各种实验条件下，孕酮可减少啮齿动物的攻击行为，但有人可能会认为，这种作用是由于某些类固醇众所周知的麻醉/镇静特性所致。我们通过比较孕酮和麻醉性孕激素α-香附酮对仓鼠攻击行为、生殖行为和运动行为的影响来检验这一假设。运动被用作镇静/催眠作用的敏感指标。孕酮减少了攻击行为，而没有抑制动物的总体运动活动，并且它还促进了两性的雌性性行为。α-香附酮在仓鼠中诱导了轻度镇静，但这并没有减少它们的攻击表现。α-香附酮在两性中均未促进雌性性行为。我们认为，孕酮对仓鼠攻击性的抑制作用不太可能源于该激素的镇静特性。
