Trivulzio S
Department of Pharmacology Chemotherapy and Medical Toxicology, University of Milan.
Pharmacol Res Commun. 1988 Dec;20(12):1035-46. doi: 10.1016/s0031-6989(88)80725-2.
2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects. The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole. The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pilocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine. BIU probably depresses gastric acid secretion by interfering with both histamine and acetylcholine receptors.
2-苯并咪唑脲（BIU）可减少胃酸分泌。其抗分泌活性似乎与抗组胺和抗毒蕈碱作用有关。BIU的抗组胺活性源于其对倍他唑刺激的胃酸分泌的抑制作用以及对倍他唑刺激的离体豚鼠耳廓的抑制活性。BIU的抗毒蕈碱活性可从多个实验中看出：该分子可减少卡巴胆碱刺激的大鼠胃酸分泌，抑制麻醉猫体内新斯的明刺激的十二指肠运动，减轻毛果芸香碱引起的离体豚鼠气管张力亢进，还可抑制乙酰胆碱刺激的豚鼠回肠活动。BIU可能通过干扰组胺和乙酰胆碱受体来抑制胃酸分泌。
