Stanić Snežana M, Matić Sanja Lj
University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
University of Kragujevac, Institute for Information Technologies, Department of Sciences, Jovana Cvijića bb, 34000 Kragujevac, Serbia
Theor Biol Forum. 2019 Jan 1;112(1-2):79-89. doi: 10.19272/201911402006.
Aging is a natural, time-dependent process characterized by irreversible changes in the molecules, cells, tissues, and organs. It occurs as a result of cumulative damage at different levels of the organization, in particular by damaging proteins and DNA. There is no single definition, nor a unique attitude about when and how age arises and what are its causes. The process is extremely complex and most likely a consequence of the effects of different mechanisms (not only genetic but also acquired) that lead to disrupt homeostasis, reduce stress resistance and the more frequent occurrence of the disease. There are many classifications of theories about aging and they often contradict one another. No one theory is sufficiently able to explain the process of aging. The aim of this work is to analyze the different aspects, main characteristics of the aging, individual differences in the speed of this process and theories about the mechanisms of aging.
衰老 是一个自然的、随时间变化的过程，其特征是分子、细胞、组织和器官发生不可逆的变化。它是由于组织不同层面的累积损伤而发生的，特别是蛋白质和DNA受到损伤。对于衰老何时以及如何出现及其原因，没有单一的定义，也没有独特的看法。这个过程极其复杂，很可能是不同机制（不仅是遗传机制，还有后天机制）作用的结果，这些机制导致体内平衡失调、应激抵抗力降低以及疾病更频繁地发生。关于衰老的理论有很多分类，而且它们常常相互矛盾。没有一种理论能够充分解释衰老过程。这项工作的目的是分析衰老的不同方面、主要特征、这个过程速度的个体差异以及衰老机制的理论。
