Department of Allergy/Clinical Immunology and SA Pathology, Flinders Medical Centre, Bedford Park, South Australia, Australia,
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia,
Int Arch Allergy Immunol. 2020;181(5):357-364. doi: 10.1159/000506199. Epub 2020 Mar 3.
One of the most important blood tests in the field of allergy, mast cell tryptase has numerous diagnostic uses, particularly for anaphylactic reactions and for the diagnosis of mastocytosis. However, there are numerous other non-anaphylactic conditions where clinicians may see elevated serum tryptase (hypertryptasemia) and the practicing clinician ought to be aware of these important differential diagnoses. Such conditions include systemic mastocytosis, hematological malignancies, and chronic kidney disease. This article provides a comprehensive, updated summary on the variety of non-anaphylactic conditions where hypertryptasemia may be seen.
在过敏领域，其中一项最重要的血液检测是肥大细胞类胰蛋白酶，它具有多种诊断用途，尤其是用于诊断过敏反应和肥大细胞增多症。然而，还有许多其他非过敏的情况下，临床医生可能会看到血清类胰蛋白酶升高（高类胰蛋白酶血症），而临床医生应该了解这些重要的鉴别诊断。此类情况包括系统性肥大细胞增多症、血液系统恶性肿瘤和慢性肾脏病。本文提供了一个全面更新的关于可能出现高类胰蛋白酶血症的各种非过敏情况的总结。
