注射器的搅动和硅油的释放。
Agitation of the syringe and release of silicone oil.
机构信息
Hospital de Olhos de Sergipe, Aracaju-SE, Brazil.
Tiradentes University - UNIT, Aracaju-SE, Brazil.
出版信息
Eye (Lond). 2020 Dec;34(12):2242-2248. doi: 10.1038/s41433-020-0800-9. Epub 2020 Mar 3.
BACKGROUND/OBJECTIVES: To investigate whether agitation promotes the release of silicone oil by different models of syringe used for intravitreal injection.
METHODS
This lab study analyzed eight syringe models by light microscopy for the release of silicone oil under agitation (flick), without agitation, and positive controls. Fourier-Transform Infrared Spectroscopy (FTIR) was performed to identify the molecular compounds inside the syringes.
RESULTS
A total of 240 syringes were analyzed. The presence of silicone oil droplets was observed in all positive controls. When agitated by flicking, 100% of the samples of the syringes disclosed silicone oil, except the BD Plastipak syringe, which presented 40% of positivity. Without agitation, a smaller percentage of samples with silicone oil was observed. Agitation by flicking had a 265-fold greater chance of presenting oil droplets when compared with the syringes without agitation. There was a statistically significant difference between the three conditions (P < 0.05). Analysis of the tip of the plunger rubber by FTIR indicated the presence of polysiloxane (silicone oil) in all models of syringe.
CONCLUSIONS
Agitation of the syringe promotes the release of silicone oil. It is recommended to improve the technique of injection and the manufacture of specific syringes for ophthalmological use.
背景/目的：研究不同型号的玻璃体腔内注射用注射器在震荡（弹拨）时是否会促进硅油的释放。
方法
本实验室研究通过光镜分析了 8 种注射器模型在震荡（弹拨）、无震荡和阳性对照下硅油的释放情况。傅里叶变换红外光谱（FTIR）用于鉴定注射器内的分子化合物。
结果
共分析了 240 个注射器。所有阳性对照均观察到硅油液滴的存在。当弹拨震荡时，除了 BD Plastipak 注射器外，所有注射器的样本均显示有硅油，阳性率为 100%。无震荡时，观察到含有硅油的样本比例较小。与无震荡相比，弹拨震荡时出现油滴的可能性增加了 265 倍。三种情况之间存在统计学差异（P<0.05）。对柱塞橡胶尖端进行 FTIR 分析表明，所有注射器模型中均存在聚硅氧烷（硅油）。
结论
注射器的震荡促进了硅油的释放。建议改进注射技术并制造专门用于眼科的注射器。
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