Wang C, Zhou J A, Xie J Y, Zhou J L, Guan H P
Department of Cardiac Surgery, Union Hospital, Tongji Medical University, Wuhan, Hubei, China.
Thorac Cardiovasc Surg. 1988 Jun;36(3):141-5.
Anisodamine, a new M-cholinergic blocker discovered in China, was employed in experimental dogs on cardiopulmonary bypass (CPB) with a view to observing its hypotensive activities. Before bypass an intravenous bolus injection of anisodamine 5 mg/kg caused a transient fall of about 20 mmHg in arterial blood pressure for 10 to 15 minutes, with an increase of about 10 mmHg in pulse pressure, indicating lowering afterload. During bypass, a continuous intravenous drip of anisodamine brought about 27 to 37 mmHg fall in perfusion pressure (compared with the control group) while the perfusion flow rate was kept constant. Beneficial effects of anisodamine were manifested, post-bypass, by enhancement of cardiac output, lack of elevation of pulmonary arterial pressure, a speedy recovery of the ST segment to normal, and a decrease of the rate-pressure product, as results of circulatory improvement and myocardial protection.
山莨菪碱是中国发现的一种新型M胆碱能阻滞剂，用于在体外循环（CPB）的实验犬身上，以观察其降压活性。在体外循环前，静脉推注5mg/kg山莨菪碱会使动脉血压短暂下降约20mmHg，持续10至15分钟，脉压增加约10mmHg，表明后负荷降低。在体外循环期间，持续静脉滴注山莨菪碱使灌注压下降27至37mmHg（与对照组相比），而灌注流速保持恒定。体外循环后，山莨菪碱的有益作用表现为心输出量增加、肺动脉压未升高、ST段迅速恢复正常以及心率-血压乘积降低，这是循环改善和心肌保护的结果。
