Liu Kuo, Xi Bo, Liu Zheng, Qi Han, Liu Bin, Zhang Jie, Cao Han, Yan Yuxiang, Zhao Min, He Yan, Zhang Ling
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
Int J Hypertens. 2020 Feb 17;2020:3167875. doi: 10.1155/2020/3167875. eCollection 2020.
Genome-wide association studies and candidate gene studies have found many single nucleotide polymorphisms (SNPs) that affect salt sensitivity (SS). We constructed a polygenic risk score (PRS) to estimate the joint effect of these SNPs on SS.
We recruited 762 Chinese participants into the study. An unweighted PRS was constructed using 42 known genetic risk variants associated with SS or salt sensitivity blood pressure. A modified Sullivan's acute oral saline load and diuresis shrinkage test was used to detect salt sensitivity. Logistic regression was used to estimate the joint effect of the SNPs on SS both overall and after stratification by hypertension.
The mean age of the participants was 57.1 years, and most of them were female (77.4%). The prevalence of SS was 28.7%. Both the continuous PRS and PRS tertiles were significantly associated with the risk of SS and a BP increase of more than 5 mmHg during acute salt loading but were not associated with a BP decrease of more than 10 mmHg during the diuresis shrinkage process. In the normotensive group, participants with PRSs in the middle and top tertiles had a more than twofold increased risk of SS (OR = 2.18, 95% CI: 1.15-4.12, = 0.016, and OR = 2.28, 95% CI: 1.19-4.38, = 0.016, and OR = 2.28, 95% CI: 1.19-4.38, = 0.016, and OR = 2.28, 95% CI: 1.19-4.38, = 0.016, and OR = 2.28, 95% CI: 1.19-4.38.
The 42 investigated SNPs were jointly and significantly associated with SS, especially in the normotensive Chinese population. These findings may provide genetic evidence for identifying target populations that would benefit from salt restriction policies.
全基因组关联研究和候选基因研究发现了许多影响盐敏感性（SS）的单核苷酸多态性（SNP）。我们构建了一个多基因风险评分（PRS）来评估这些SNP对SS的联合效应。
我们招募了762名中国参与者进入本研究。使用42个与SS或盐敏感性血压相关的已知遗传风险变异构建了一个未加权的PRS。采用改良的沙利文急性口服盐水负荷和利尿收缩试验来检测盐敏感性。使用逻辑回归评估SNP对SS的总体联合效应以及按高血压分层后的联合效应。
参与者的平均年龄为57.1岁，其中大多数为女性（77.4%）。SS的患病率为28.7%。连续PRS和PRS三分位数均与SS风险以及急性盐负荷期间血压升高超过5 mmHg显著相关，但与利尿收缩过程中血压降低超过10 mmHg无关。在正常血压组中，处于PRS中间和最高三分位数的参与者患SS的风险增加了两倍多（OR = 2.18，95% CI：1.15 - 4.12，P = 0.016；OR = 2.28，95% CI：1.19 - 4.38，P = 0.016；OR = 2.28，95% CI：1.19 -
4.38，P = 0.016；OR = 2.28，95% CI：1.19 - 4.38，P = 0.016；OR = 2.28，95% CI：1.19 - 4.38）。
所研究的42个SNP与SS显著联合相关，尤其是在正常血压的中国人群中。这些发现可能为识别将从限盐政策中受益的目标人群提供遗传证据。
