Sugai Keiko, Michikawa Takehiro, Takebayashi Toru, Nishiwaki Yuji
Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan.
Age Ageing. 2020 Jul 1;49(4):592-598. doi: 10.1093/ageing/afaa024.
The effect of knee osteoarthritis, which causes knee pain, on higher-level functional competence (HLFC) is not clear.
To clarify the effect of knee pain on HLFC in older people.
Community-based prospective cohort study.
Kurabuchi town, Gumma prefecture, Japan.
Community-dwelling individuals aged 65 and older.
A total of 808 residents participated to the baseline examinations. The frequency of knee pain, degree of pain and functional impairment resulting from the pain were asked at baseline (2005-2006) via a self-administered questionnaire in Japanese based on an English version of the Western Ontario and McMaster Universities Osteoarthritis Index. Information on HLFC at baseline and during home visits were collected annually until 2014 with the Tokyo Metropolitan Institute of Gerontology Index of Competence. The association between baseline knee pain and HLFC decline was assessed with a Cox proportional hazards model.
Two factors, persistent knee pain and severe functional impairment caused by the pain, were significantly associated with future declines in total HLFC, with adjusted hazard ratios (95% confidence intervals) of 1.51 (1.08-2.11) and 1.49 (1.10-2.00). In analysis by subcategory, persistent knee pain had a significant adverse effect on participants' intellectual and social activities, and that severe physical functional impairment also had a significant impact on social activities.
The clear association of the frequency of knee pain and resultant functional impairment with future HLFC decline indicates that collecting information about these factors may be useful in identifying older people at high risk of future HLFC decline.
导致膝关节疼痛的膝骨关节炎对高级功能能力(HLFC)的影响尚不清楚。
阐明膝关节疼痛对老年人HLFC的影响。
基于社区的前瞻性队列研究。
日本群马县仓渊町。
65岁及以上的社区居住个体。
共有808名居民参加了基线检查。在基线时(2005 - 2006年),通过基于英文版西安大略和麦克马斯特大学骨关节炎指数的日文自填问卷,询问膝关节疼痛的频率、疼痛程度以及疼痛导致的功能障碍。使用东京都老人综合研究所能力指数,每年收集基线时和家访期间的HLFC信息,直至2014年。采用Cox比例风险模型评估基线膝关节疼痛与HLFC下降之间的关联。
两个因素,即持续性膝关节疼痛和疼痛导致的严重功能障碍,与未来总HLFC下降显著相关,调整后的风险比(95%置信区间)分别为1.51(1.08 - 2.11)和1.49(1.10 - 2.00)。在按亚类分析中,持续性膝关节疼痛对参与者的智力和社交活动有显著不利影响,严重的身体功能障碍对社交活动也有显著影响。
膝关节疼痛频率和由此导致的功能障碍与未来HLFC下降之间的明确关联表明,收集这些因素的信息可能有助于识别未来HLFC下降风险较高的老年人。