能量饮料中天然 GHB 的存在证据：在疑似 DFSA 案例中对数据解释应保持谨慎。

Evidence of Natural GHB Presence in Energy Drinks: Caution in Data Interpretation in Suspected DFSA Cases.

机构信息

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.

出版信息

J Anal Toxicol. 2020 Dec 12;44(8):811-817. doi: 10.1093/jat/bkaa025.

DOI:10.1093/jat/bkaa025

PMID:32128576

Abstract

Gamma-hydroxybutyric acid (GHB), usually reported as rape drug in drug-facilitated sexual assaults (DFSA), is an endogenous substance in human body and is also found in many beverages. This may lead to data misinterpretation in forensic cases. Herein, we aimed to collect evidence about natural GHB presence in 13 energy drinks (ED). After a liquid-liquid extraction with acidic ethyl acetate, samples were derivatized with BSTFA 1% TMCS. Analyses were carried out by a GC-MS system in SIM mode (GHB, 233, 234, 143 and 147 m/z; GHB-d6, 239, 240, 120 and 206 m/z). GHB was present in all the samples at very low concentrations ranging from 98 to 197 ng/mL. Thus, GHB presence in ED is not exclusively related to exogenous addition. Since the GHB levels are far lower than the minimum active dose (i.e., 0.5 g), it is not expected to induce any effect.

摘要

γ-羟基丁酸（GHB）通常在药物辅助性性侵犯（DFSA）中被报告为强奸药物，它是人体内的一种内源性物质，也存在于许多饮料中。这可能导致法医案例中的数据解释错误。在此，我们旨在收集 13 种能量饮料（ED）中天然 GHB 存在的证据。经过酸性乙酸乙酯的液-液萃取后，样品用 BSTFA 1% TMCS 衍生化。通过 GC-MS 系统在 SIM 模式下进行分析（GHB，233、234、143 和 147 m/z；GHB-d6，239、240、120 和 206 m/z）。GHB 存在于所有样品中，浓度非常低，范围在 98 至 197 ng/mL 之间。因此，ED 中 GHB 的存在并不完全与外源添加有关。由于 GHB 水平远低于最小有效剂量（即 0.5 g），预计不会产生任何影响。