Department of Di Diagnostica Per Immagini, Radioterapia Oncologica Ed Ematologia, UOC Radiologia e Neuroradiologia, Roma, Italia.
Department of Di Scienze Dell'Invecchiamento, Neurologiche, Ortopediche e Della Testa-Collo, UOC Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Neurol India. 2020 Jan-Feb;68(1):192-198. doi: 10.4103/0028-3886.279674.
A 38-year-old woman 12 days after delivery of her second pregnancy was admitted to emergency room for a severe occipital headache started 3 days before, associated with confusion, nausea, vomiting and walking impairment. Neurological examination showed left hemiparesis, hypoesthesia in left arm and leg. Brain computer tomography images showed a large intraparenchymal hematoma in the right frontoparietal lobes with mass effect on adjacent subarachnoid spaces and on lateral ventricle. The third day during hospitalization, the patient experienced a sudden worsening of the neurological symptoms and a severe headache peaking within 1 minute (min); a new brain computed tomography and brain magnetic revealed another small intraparenchymal hematoma in the left parietal lobe with increase of the amount of subarachnoid hemorrhage. Digital subtraction angiography discloses multifocal narrowing of the middle and small arteries in both anterior and posterior circulation with a relative spare of large vessels. Postpartum reversible cerebral vasoconstriction syndrome with intracranial hemorrhage is a rare clinical condition that can be misdiagnosed with other dramatic neurological diseases such as eclamptic encephalopathy, cortical venous thrombosis, primary angiitis of the central nervous system or posterior reversible encephalopathy syndrome with whom may share predisposing factors and neurological presentation but clinical course, treatment and prognosis is quite different and emergency physicians and neurologists should consider this diagnosis in postpartum patients with hemorrhage.
一位 38 岁的女性,在第二次妊娠分娩后 12 天,因严重的枕部头痛就诊于急诊室,头痛始于 3 天前,伴有意识模糊、恶心、呕吐和行走障碍。神经系统检查显示左侧偏瘫,左上肢和下肢感觉减退。脑计算机断层扫描图像显示右侧额顶叶有大的脑实质血肿,伴有相邻蛛网膜下腔和侧脑室的占位效应。住院第 3 天,患者突然出现神经症状恶化和剧烈头痛,持续 1 分钟(min);新的脑计算机断层扫描和脑磁共振成像显示左侧顶叶有另一个小的脑实质血肿,蛛网膜下腔出血量增加。数字减影血管造影显示前后循环中小动脉多处狭窄,大血管相对保留。产后可逆性脑动脉收缩综合征伴颅内出血是一种罕见的临床情况,可能与其他戏剧性的神经系统疾病(如子痫性脑病、皮质静脉血栓形成、中枢神经系统原发性血管炎或后部可逆性脑病综合征)相混淆,这些疾病可能有共同的易患因素和神经表现,但临床过程、治疗和预后有很大的不同,急诊医生和神经科医生应考虑在产后出血患者中诊断这种疾病。