School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK.
Institute of Microbiology and Infection, University of Birmingham, B15 2TT, UK.
Chem Commun (Camb). 2020 Apr 4;56(26):3729-3732. doi: 10.1039/c9cc08189e. Epub 2020 Mar 4.
The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applied to lanthanide coiled coils.
通过精心选择第二配体端基残基，包括使用较少的色氨酸，可在整个整数范围内（3→0 个水合配体）逐渐调节设计的螺旋线圈中的金属水合状态。潜在的影响包括应用于镧系元素螺旋线圈时 MRI 弛豫率的四倍变化。
